STRN4 and DFFA

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		STRN4	DFFA
Description		striatin 4	DNA fragmentation factor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite Protein-containing Complex Neuronal Cell Body Dendritic Spine FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding Calmodulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Protein Binding Protein Domain Specific Binding Protein Folding Chaperone Deoxyribonuclease Inhibitor Activity
	Biological Process	Negative Regulation Of Hippo Signaling Regulation Of Modification Of Postsynaptic Structure	Apoptotic DNA Fragmentation Protein Folding Apoptotic Process Negative Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation
Pathways			Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Primary sclerosing cholangitis ( 23603763)	Depression in smokers ( 30219690) Male-pattern baldness ( 28196072 29146897)
Interacting Genes		28 interacting genes: AK5 ASNS CALM1 CAV1 CLDN12 CRK DDX39B DFFA ECSIT GDF9 JUN KLHDC2 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MIF MSANTD2 MTG1 NBEA PBDC1 PI4KA PLPPR3 PPBP SLC25A6 TNIK WIPI2 WNT7A	12 interacting genes: AGO2 CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ
Entrez ID		29888	1676
HPRD ID		18125	03531
Ensembl ID		ENSG00000090372	ENSG00000160049
Uniprot IDs		F5GYK2 Q59GV6 Q9NRL3	O00273
PDB IDs			1IBX 1IYR 1KOY
Enriched GO Terms of Interacting Partners?		MAP Kinase Kinase Kinase Kinase Activity MAPK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of JNK Cascade Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Kinase Activity Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Transforming Growth Factor Beta Stimulus Nucleotide Binding ATP Binding Response To Transforming Growth Factor Beta Protein Serine Kinase Activity Protein Phosphorylation Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Cytokine Activity Regulation Of Fibroblast Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential	Execution Phase Of Apoptosis Cellular Response To Staurosporine Pyroptotic Inflammatory Response Cell Death Apoptotic Process Programmed Cell Death Protein Domain Specific Binding Fibroblast Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Positive Regulation Of Immune Response To Tumor Cell Regulation Of Amyloid Precursor Protein Biosynthetic Process Aspartic-type Endopeptidase Activity Regulation Of Primary Metabolic Process Regulation Of Synapse Maturation Peptidase Activity Plasma Membrane Repair Regulation Of Response To Tumor Cell Negative Regulation Of Translation Cellular Response To Alkaloid Regulation Of Glycoprotein Biosynthetic Process Hydrolase Activity Cytoplasm Protein Sequestering Activity Leukocyte Apoptotic Process Neuron Recognition Glutamatergic Synapse Negative Regulation Of Translational Initiation Postsynapse Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process Ceramide Biosynthetic Process Identical Protein Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Regulation Of Metabolic Process Proteolysis Cysteine-type Endopeptidase Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Synapse Organization Striated Muscle Cell Differentiation Response To External Biotic Stimulus Phospholipase A2 Activator Activity Cytolytic Granule Lumen Leukocyte Mediated Cytotoxicity Synaptic Target Recognition Endoribonuclease Activity, Cleaving MiRNA-paired MRNA Negative Regulation Of G Protein-coupled Receptor Internalization
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