MAP4K3

Description		mitogen-activated protein kinase kinase kinase kinase 3
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GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Bone mineral density ( 31790847)
Novel Interacting Genes		10 novel interacting genes: ACE2 BIN1 COPS5 HNRNPLL ITSN2 PPP2CA SH3GL2 SH3RF1 SORBS1 STRN4
Interacting Genes		10 interacting genes: ACE2 BIN1 COPS5 HNRNPLL ITSN2 PPP2CA SH3GL2 SH3RF1 SORBS1 STRN4
Entrez ID		8491
HPRD ID		05373
Ensembl ID		ENSG00000011566
Uniprot IDs		A8K602 B3KMM5 B4DSS3 F5H5A3 Q8IVH8
PDB IDs		5J5T
Enriched GO Terms of Interacting Partners?		Presynaptic Endocytosis Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse FAR/SIN/STRIPAK Complex Endocytosis Negative Regulation Of Hippo Signaling Import Into Cell Vesicle-mediated Transport Tau Protein Binding Regulation Of Hippo Signaling Membrane Raft Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction Negative Regulation Of Signal Transduction Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Signaling RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Negative Regulation Of Signaling Macrophage Migration Inhibitory Factor Binding Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Synapse Regulation Of Striated Muscle Contraction Negative Regulation Of Blood-brain Barrier Permeability Entry Receptor-mediated Virion Attachment To Host Cell Cytoplasm Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Exosomal Secretion Viral Translation Viral Life Cycle Regulation Of Macromolecule Metabolic Process Synaptic Vesicle Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Action Potential Positive Regulation Of Cellular Component Biogenesis Regulation Of Generation Of Precursor Metabolites And Energy
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