GUCA1A and BCKDK

		GUCA1A	BCKDK
Description		guanylate cyclase activator 1A	branched chain keto acid dehydrogenase kinase
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Cell Projection Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex
	Molecular Function	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein
	Biological Process	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency
Drugs		Myristic acid	Adenosine 5'-[gamma-thio]triphosphate
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Spatial processing ( 31596458)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)
Interacting Genes		10 interacting genes: AGR2 BCKDK C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B	21 interacting genes: APP BCKDHB CDIPT EIF3C EPS8 FBXO7 FOXO1 FXR1 FXR2 GUCA1A LSM8 NR5A2 PCDHB9 QPRT SETD1A SPTA1 STAT3 TAOK2 TRAF4 UBC ZNF267
Entrez ID		2978	10295
HPRD ID		02648	12523
Ensembl ID		ENSG00000048545	ENSG00000103507
Uniprot IDs		P43080	O14874
PDB IDs			8F5F 8F5J 8F5S 9DI9
Enriched GO Terms of Interacting Partners?			Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission
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