BCKDK and SETD1A

		BCKDK	SETD1A
Description		branched chain keto acid dehydrogenase kinase	SET domain containing 1A, histone lysine methyltransferase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein	Nucleic Acid Binding RNA Binding Protein Binding Beta-catenin Binding Methyltransferase Activity Transferase Activity Histone H3K4 Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Brain Development Methylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization
Pathways		Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Parkinson's disease ( 31660654) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Red blood cell count ( 32888494)
Interacting Genes		21 interacting genes: APP BCKDHB CDIPT EIF3C EPS8 FBXO7 FOXO1 FXR1 FXR2 GUCA1A LSM8 NR5A2 PCDHB9 QPRT SETD1A SPTA1 STAT3 TAOK2 TRAF4 UBC ZNF267	7 interacting genes: BCKDK DPY30 EP300 H3C1 H3C14 LBP TAOK2
Entrez ID		10295	9739
HPRD ID		12523	13795
Ensembl ID		ENSG00000103507	ENSG00000099381
Uniprot IDs		O14874	O15047
PDB IDs		8F5F 8F5J 8F5S 9DI9	3S8S 3UVN 4EWR 8ILY
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission	Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Tau Protein Binding Chromatin Organization Epigenetic Regulation Of Gene Expression Peptidyl-lysine Propionylation Swimming Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Transcription Initiation-coupled Chromatin Remodeling Histone Butyryltransferase Activity Histone Crotonyltransferase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Structural Constituent Of Chromatin Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Regulation Of Glucose Metabolic Process Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Nucleosome Assembly N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Nucleosome Nucleosome Organization Basal Dendrite Morphogenesis Basal Dendrite Arborization Negative Regulation Of Protein Oligomerization Catalytic Activity, Acting On A Protein Chromosome Isoleucine Metabolic Process L-isoleucine Catabolic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity L-valine Catabolic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Innate Immune Response-activating Signaling Pathway Lipoteichoic Acid Binding Protein-DNA Complex Assembly Valine Metabolic Process L-leucine Catabolic Process Positive Regulation Of TORC2 Signaling
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