TMEM14A and USP18

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		TMEM14A	USP18
Description		transmembrane protein 14A	ubiquitin specific peptidase 18
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity ISG15-specific Peptidase Activity Molecular Adaptor Activity
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Proteolysis Response To Bacterium Protein Deubiquitination Regulation Of Protein Stability Response To Stilbenoid Regulation Of Inflammatory Response Response To Other Organism Negative Regulation Of Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways			ISG15 antiviral mechanism TAK1-dependent IKK and NF-kappa-B activation Ub-specific processing proteases Regulation of IFNA/IFNB signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Response to hepatitis B vaccine ( 29534301)	Systemic lupus erythematosus ( 33272962)
Interacting Genes		39 interacting genes: AQP6 CLN8 CPLX4 CREB3 CREB3L1 CXCR3 ERBB3 ERBB4 ERGIC3 ERMAP FAM209A FKBP7 IER3IP1 KCNK5 LMNA LRCH1 LXN MMGT1 MTNR1A MTNR1B MUC1 NEMP1 PDZK1IP1 SAR1A SCN3B SERINC2 SLC10A6 SLC18A1 SLC19A3 SLC35H1 SLC7A1 SSMEM1 TMEM14B TMEM179B TMEM31 TMEM51 TMEM80 TMEM86B USP18	6 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17
Entrez ID		28978	11274
HPRD ID		15522	06136
Ensembl ID		ENSG00000096092	ENSG00000184979
Uniprot IDs		Q9Y6G1	Q9UMW8
PDB IDs		2LOO 2LOP
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Apoptotic Process Neuregulin Receptor Activity Negative Regulation Of Programmed Cell Death Melatonin Receptor Activity Transmembrane Transport	Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Bone Mineralization Cell Proliferation Involved In Heart Valve Development Perforant Pathway To Dendrate Granule Cell Synapse Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Ossification Embryonic Camera-type Eye Formation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Signal Transduction JAK Pathway Signal Transduction Adaptor Activity Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Protein Oligomerization Regulation Of Cell Communication Regulation Of Signaling Protein-cysteine S-myristoyltransferase Activity ISG15-protein Conjugation Protein-cysteine S-stearoyltransferase Activity Cardiac Neural Crest Cell Development Involved In Heart Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cranial Suture Morphogenesis Mitral Valve Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Fatty Acid Beta-oxidation Outer Ear Morphogenesis
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