USP18 and ISG15

Number of citations of the paper that reports this interaction (PubMedID 35258551)
42

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (two hybrid)

		USP18	ISG15
Description		ubiquitin specific peptidase 18	ISG15 ubiquitin like modifier
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity ISG15-specific Peptidase Activity Molecular Adaptor Activity	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Proteolysis Response To Bacterium Protein Deubiquitination Regulation Of Protein Stability Response To Stilbenoid Regulation Of Inflammatory Response Response To Other Organism Negative Regulation Of Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion
Pathways		ISG15 antiviral mechanism TAK1-dependent IKK and NF-kappa-B activation Ub-specific processing proteases Regulation of IFNA/IFNB signaling Regulation of NF-kappa B signaling	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 33272962)	Blood protein levels ( 30072576)
Interacting Genes		6 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17	25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5
Entrez ID		11274	9636
HPRD ID		06136	00958
Ensembl ID		ENSG00000184979	ENSG00000187608
Uniprot IDs		Q9UMW8	P05161
PDB IDs			1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Bone Mineralization Cell Proliferation Involved In Heart Valve Development Perforant Pathway To Dendrate Granule Cell Synapse Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Ossification Embryonic Camera-type Eye Formation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Signal Transduction JAK Pathway Signal Transduction Adaptor Activity Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Protein Oligomerization Regulation Of Cell Communication Regulation Of Signaling Protein-cysteine S-myristoyltransferase Activity ISG15-protein Conjugation Protein-cysteine S-stearoyltransferase Activity Cardiac Neural Crest Cell Development Involved In Heart Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cranial Suture Morphogenesis Mitral Valve Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Fatty Acid Beta-oxidation Outer Ear Morphogenesis	Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding
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