USP18

Description		ubiquitin specific peptidase 18
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity ISG15-specific Peptidase Activity Molecular Adaptor Activity
	Biological Process	Proteolysis Response To Bacterium Protein Deubiquitination Regulation Of Protein Stability Response To Stilbenoid Regulation Of Inflammatory Response Response To Other Organism Negative Regulation Of Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways		ISG15 antiviral mechanism TAK1-dependent IKK and NF-kappa-B activation Ub-specific processing proteases Regulation of IFNA/IFNB signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 33272962)
Novel Interacting Genes		6 novel interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17
Interacting Genes		6 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17
Entrez ID		11274
HPRD ID		06136
Ensembl ID		ENSG00000184979
Uniprot IDs		Q9UMW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Bone Mineralization Cell Proliferation Involved In Heart Valve Development Perforant Pathway To Dendrate Granule Cell Synapse Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Ossification Embryonic Camera-type Eye Formation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Signal Transduction JAK Pathway Signal Transduction Adaptor Activity Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Protein Oligomerization Regulation Of Cell Communication Regulation Of Signaling Protein-cysteine S-myristoyltransferase Activity ISG15-protein Conjugation Protein-cysteine S-stearoyltransferase Activity Cardiac Neural Crest Cell Development Involved In Heart Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cranial Suture Morphogenesis Mitral Valve Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Fatty Acid Beta-oxidation Outer Ear Morphogenesis
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