GIT1 and KLHL4

Number of citations of the paper that reports this interaction (PubMedID 37495603)
95

Data Source:
BioGRID (affinity chromatography technology, pull down)

		GIT1	KLHL4
Description		GIT ArfGAP 1	kelch like family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytoskeleton Cilium Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Ciliary Basal Body
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding	Actin Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Alzheimer's disease ( 30636644)
Interacting Genes		56 interacting genes: ARHGEF6 ARHGEF7 B9D1 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	3 interacting genes: DSCAM GIT1 RPL36
Entrez ID		28964	56062
HPRD ID		06577	02283
Ensembl ID		ENSG00000108262	ENSG00000102271
Uniprot IDs		Q59FC3 Q9Y2X7	A5PKX1 Q9C0H6
PDB IDs
Enriched GO Terms of Interacting Partners?		Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization	Dendritic Spine Development Protein Tyrosine Kinase Binding Cell Recognition Growth Cone Synapse Negative Regulation Of ARF Protein Signal Transduction Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Locomotory Behavior Structural Constituent Of Postsynaptic Specialization Synapse Organization Positive Regulation Of Axon Extension Involved In Axon Guidance Intramembranous Ossification Motor Learning Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation Regulation Of Phosphorus Metabolic Process Eye Photoreceptor Cell Differentiation Dendrite Photoreceptor Cell Differentiation Cell Junction Organization Positive Regulation Of Receptor Catabolic Process Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Regulation Of ARF Protein Signal Transduction Immunological Synapse Formation Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Glycolytic Process Regulation Of Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding Inhibitory Synapse Calyx Of Held Postsynaptic Density Organization Synaptic Vesicle Recycling Postsynaptic Specialization Organization Negative Regulation Of ATP Metabolic Process Retina Layer Formation Maintenance Of Synapse Structure Excitatory Synapse Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Microtubule Polymerization Gamma-tubulin Binding Cell-cell Adhesion Mediator Activity Positive Regulation Of Axon Extension Mitotic Spindle Pole
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