GIT1 and KIF1A

Number of citations of the paper that reports this interaction (PubMedID 12522103)
0

Data Source:
HPRD (in vivo)

		GIT1	KIF1A
Description		GIT ArfGAP 1	kinesin family member 1A
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Membrane Axon Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Neuronal Dense Core Vesicle Neuronal Dense Core Vesicle Membrane Axon Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process	Microtubule-based Movement Anterograde Axonal Transport Transport Along Microtubule Vesicle-mediated Transport Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs			Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Response to placebo treatment in childhood asthma (FVC change) ( 31557306)
Interacting Genes		56 interacting genes: ARHGEF6 ARHGEF7 B9D1 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	33 interacting genes: ADAMTSL4 AR DSCR9 DYRK1A ESR1 FXR2 GIT1 ICAM1 MDFI MED1 MID2 MKRN3 MTUS2 NOTCH2NLA PCNT PKNOX1 PLSCR1 PPARG PSMA3 RBPMS RFX6 RGS20 RNF31 RSPH1 RXRA SP1 SPRY2 TNS2 TRAF1 TRIM27 TRIP6 TSPOAP1 VPS26C
Entrez ID		28964	547
HPRD ID		06577	03156
Ensembl ID		ENSG00000108262	ENSG00000130294
Uniprot IDs		Q59FC3 Q9Y2X7	A0A3B3IT28 A0A3B3ITE5 A0A3B3ITF7 A0A3B3ITK3 A0A3B3ITW6 A0A3B3IU40 A0A3B3IUA1 A0A3F2YNW9 C9JBH1 Q12756
PDB IDs			4EGX 4EJQ 4UXO 4UXP 4UXR 4UXS 8UTN 8UTO 8UTP 8UTQ 8UTR 8UTS 8UTT 8UTU 8UTV 8UTW 8UTY
Enriched GO Terms of Interacting Partners?		Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization	Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding LBD Domain Binding Regulation Of Signal Transduction Nuclear Receptor-mediated Signaling Pathway Transcription Coregulator Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Monocyte Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Cytoplasm Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription By RNA Polymerase II Mammary Gland Branching Involved In Pregnancy DNA Binding Domain Binding Positive Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Lipoprotein Transport Negative Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Communication Negative Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Signaling Enzyme Binding MRNA Transcription By RNA Polymerase II Organ Growth Positive Regulation Of Signal Transduction Transcription Coactivator Binding Transcription Cis-regulatory Region Binding DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Prostate Gland Growth
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