GIT1 and PAK3

Number of citations of the paper that reports this interaction (PubMedID 10896954)
0

Data Source:
HPRD (in vivo)

		GIT1	PAK3
Description		GIT ArfGAP 1	p21 (RAC1) activated kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Cellular Response To Starvation Dendrite Development Cell Migration Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Development Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Regulation Of Actin Filament Organization
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle
Drugs			Fostamatinib
Diseases			Non-syndromic X-linked mental retardation
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		56 interacting genes: ARHGEF6 ARHGEF7 B9D1 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1
Entrez ID		28964	5063
HPRD ID		06577	02142
Ensembl ID		ENSG00000108262	ENSG00000077264
Uniprot IDs		Q59FC3 Q9Y2X7	B2RCU6 O75914
PDB IDs			6FD3
Enriched GO Terms of Interacting Partners?		Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization	Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Lamellipodium Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Cell Cortex Lamellipodium Regulation Of Microtubule Polymerization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Postsynapse Cell Junction Organization Cell Projection Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Or Depolymerization Actin Filament Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Lamellipodium Organization Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Plasma Membrane Bounded Cell Projection Assembly Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Substrate Adhesion-dependent Cell Spreading Cell-cell Junction Endocytosis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Signal Complex Assembly Intracellular Signaling Cassette Presynapse Thioesterase Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Regulation Of Neurotransmitter Secretion Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Stress Fiber Assembly
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