WEE2-AS1 and ERAP1

Number of citations of the paper that reports this interaction (PubMedID 36168628)
47

Data Source:
BioGRID (unspecified method)

		WEE2-AS1	ERAP1
Description		WEE2 antisense RNA 1	endoplasmic reticulum aminopeptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	U1 SnRNP	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Extracellular Exosome
	Molecular Function	Pre-mRNA 5'-splice Site Binding	Endopeptidase Activity Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	MRNA 5'-splice Site Recognition	Angiogenesis Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Assembly With MHC Class I Protein Complex Proteolysis Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis
Pathways			Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS			Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 32492107 25200001) Alcohol dependence ( 19581569) Ankylosing spondylitis ( 20062062 30946743 23749187 21743469) Behcet's disease ( 23291587) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576) Body mass index ( 26426971 29273807) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Medication use (calcium channel blockers) ( 31015401) Psoriasis ( 20953190 25854761 25574825 23143594) Psoriasis vulgaris ( 26626624) Systolic blood pressure ( 30578418) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1	4 interacting genes: H3-4 IL6R TNFRSF1A WEE2-AS1
Entrez ID		285962	51752
HPRD ID		08286	06015
Ensembl ID		ENSG00000228775	ENSG00000164307
Uniprot IDs			A0A075BTL2 Q9NZ08
PDB IDs			2YD0 3MDJ 3QNF 3RJO 5J5E 6M8P 6MGQ 6Q4R 6RQX 6RYF 6T6R 7MWB 7MWC 7Z28 9GJN 9GJS 9GK6 9GKE
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization	Extrinsic Apoptotic Signaling Pathway Ciliary Neurotrophic Factor Receptor Activity Hepatic Immune Response Receptor Complex Ciliary Neurotrophic Factor Binding Interleukin-6 Receptor Complex Interleukin-11 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Binding Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Spermatogonial Cell Division Pre-mRNA 5'-splice Site Binding Interleukin-11-mediated Signaling Pathway Defense Response To Bacterium Interleukin-6 Receptor Binding Positive Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Apoptotic Process Involved In Morphogenesis Aortic Valve Development Tumor Necrosis Factor Binding Semi-lunar Valve Development DNA Replication-dependent Chromatin Assembly MRNA 5'-splice Site Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Activity Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet Aggregation Regulation Of Cell Differentiation Negative Regulation Of Collagen Biosynthetic Process Cytokine-mediated Signaling Pathway Response To Bacterium T-helper 17 Cell Lineage Commitment Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Endocrine Pancreas Development Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Homotypic Cell-cell Adhesion U1 SnRNP Regulation Of Membrane Lipid Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment
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