TMED8 and NDUFA12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMED8	NDUFA12
Description		transmembrane p24 trafficking protein family member 8	NADH:ubiquinone oxidoreductase subunit A12
Image		No pdb structure
GO Annotations	Cellular Component		Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Protein Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process		Aerobic Respiration Mitochondrial ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 29212778 32469254) Heel bone mineral density x serum urate levels interaction ( 34046847) Myocardial infarction ( 33532862)
Interacting Genes		33 interacting genes: ADTRP AMIGO2 APOL2 ARL6IP1 C10orf67 CIAO2A CMTM5 CMTM6 CYB561D1 DEFB129 DERL1 DGAT2L6 EI24 H4C7 LAPTM4A MDK MMGT1 MRPL41 MRPS18B MTIF3 NDUFA12 PROX2 REEP6 SERP2 STX8 SUSD3 TMEM115 TMEM121 TMEM218 TMEM254 TRAM1L1 UNC50 ZDHHC16	4 interacting genes: MYO15B SYT4 TMED8 ZNF768
Entrez ID		283578	55967
HPRD ID		18201	16781
Ensembl ID		ENSG00000100580	ENSG00000184752
Uniprot IDs		Q6PL24	Q9UI09
PDB IDs			5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane	Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity Dense Core Granule Membrane Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Membrane Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Calcium Ion-dependent Exocytosis Microvesicle Dense Core Granule Cytoskeletal Transport Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Calcium-dependent Activation Of Synaptic Vesicle Fusion Somatodendritic Compartment Secretory Granule Localization Negative Regulation Of Catecholamine Secretion Dense Core Granule Positive Regulation Of Calcium Ion-dependent Exocytosis Neuronal Dense Core Vesicle Positive Regulation Of Dendrite Extension Calcium Ion Sensor Activity Astrocyte Projection Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Positive Regulation Of Amino Acid Transport Regulation Of Short-term Neuronal Synaptic Plasticity Positive Regulation Of Vesicle Fusion Regulation Of Dopamine Secretion Exocytic Vesicle Regulation Of Vesicle Fusion Regulation Of Catecholamine Secretion Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Negative Regulation Of Exocytosis Positive Regulation Of Regulated Secretory Pathway Calcium-dependent Phospholipid Binding Regulation Of Synaptic Vesicle Exocytosis
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