ZDHHC22 and CLEC4D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZDHHC22	CLEC4D
Description		zDHHC palmitoyltransferase 22	C-type lectin domain family 4 member D
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Protein Binding D-mannose Binding Carbohydrate Binding Immunoglobulin Receptor Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Protein Targeting To Membrane Protein Palmitoylation Protein Localization To Plasma Membrane	Adaptive Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Activation Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Antifungal Innate Immune Response
Pathways			Dectin-2 family Neutrophil degranulation
Drugs
Diseases
GWAS		Cerebrospinal P-tau181p levels ( 28247064) Large artery stroke ( 24262325) Smoking status (ever vs never smokers) ( 30643258) Sweet taste preference ( 32572145)
Interacting Genes		15 interacting genes: CD79A CLEC4D CLSTN3 CREB3L1 FCRL2 FNDC9 GPX8 LDLRAD4 PROX2 PVR RPRM TMEM14B TMEM86B TMEM88 TRIM59	5 interacting genes: ACTN2 ANKRD46 JAGN1 LAG3 ZDHHC22
Entrez ID		283576	338339
HPRD ID		12655	13074
Ensembl ID		ENSG00000177108	ENSG00000166527
Uniprot IDs		Q8N966	Q8WXI8
PDB IDs			2LS8 3WHD
Enriched GO Terms of Interacting Partners?		Membrane	Protein Localization To Plasma Membrane Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Protein Localization To Cell Periphery Channel Activator Activity Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Negative Regulation Of Protein Localization LIM Domain Binding Plasmacytoid Dendritic Cell Activation Negative Regulation Of Regulatory T Cell Differentiation Leukocyte Mediated Immunity MHC Class II Protein Binding Granulocyte Colony-stimulating Factor Signaling Pathway
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