GNB2 and PCBP1

Number of citations of the paper that reports this interaction (PubMedID 11591653)
29

Data Source:
HPRD (in vivo)

		GNB2	PCBP1
Description		G protein subunit beta 2	poly(rC) binding protein 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Nuclear Speck Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding GTPase Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Cadherin Binding Sequence-specific Single Stranded DNA Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport	Viral RNA Genome Replication Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)	Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Male-pattern baldness ( 28196072)
Interacting Genes		32 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CFTR CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1	57 interacting genes: ANP32A APP ARIH1 BCL2L13 CAV3 CELF2 CELF3 DARS1-AS1 ERG EWSR1 FTH1 GNB2 HMGA1 HMGB2 HNRNPD HNRNPK HNRNPLL HSPA13 HYPK IGF2BP3 KLF1 LMNA MATR3 MOGS NOVA1 OGT PABPC1 PCBP2 PCBP4 PDLIM7 PPIG PPIL3 PRPF3 PTBP1 PUF60 QKI RALY RBFOX2 RBM10 RBM11 RBM14 RBM3 RBM42 RBPMS2 SIVA1 SNCG SNRPA SRPK2 SRSF3 TCERG1 TLE5 TNFAIP3 TSC22D4 UGP2 ZCCHC10 ZNF384 ZNF830
Entrez ID		2783	5093
HPRD ID		11820	03128
Ensembl ID		ENSG00000172354	ENSG00000169564
Uniprot IDs		P62879 Q6FHM2	Q15365 Q53SS8
PDB IDs		9AVL	1WVN 1ZTG 3VKE
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction Plasma Membrane Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Cell Division Membrane Response To Alcohol Negative Regulation Of Adenylate Cyclase Activity Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Synapse Ciliary Basal Body Wound Healing Cellular Response To Forskolin G Protein-coupled Receptor Binding Midbody Response To Forskolin Positive Regulation Of Programmed Cell Death PDZ Domain Binding Response To Wounding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Ketone Hematopoietic Or Lymphoid Organ Development Regulation Of Apoptotic Process Regulation Of Steroid Metabolic Process	Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing RNA Splicing MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Metabolic Process RNA Processing MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleus MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Pre-mRNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Speck MRNA Stabilization Negative Regulation Of Gene Expression MRNA 3'-UTR Binding CRD-mediated MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability
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