GNB2 and GNG7

Number of citations of the paper that reports this interaction (PubMedID 19376773)
43

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		GNB2	GNG7
Description		G protein subunit beta 2	G protein subunit gamma 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding GTPase Binding	Protein Binding G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport	Behavioral Fear Response Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)	Chronotype ( 30696823) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Neutrophil count ( 32888494) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		32 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CFTR CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1	8 interacting genes: ACP6 GNB1 GNB2 GNB3 GNB4 GNB5 GORASP2 MPP3
Entrez ID		2783	2788
HPRD ID		11820	10376
Ensembl ID		ENSG00000172354	ENSG00000176533
Uniprot IDs		P62879 Q6FHM2	O60262
PDB IDs		9AVL
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction Plasma Membrane Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Cell Division Membrane Response To Alcohol Negative Regulation Of Adenylate Cyclase Activity Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Synapse Ciliary Basal Body Wound Healing Cellular Response To Forskolin G Protein-coupled Receptor Binding Midbody Response To Forskolin Positive Regulation Of Programmed Cell Death PDZ Domain Binding Response To Wounding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Ketone Hematopoietic Or Lymphoid Organ Development Regulation Of Apoptotic Process Regulation Of Steroid Metabolic Process	Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding GTPase Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Protein-containing Complex Binding Lysosomal Membrane Synapse GTPase Activator Complex G-protein Gamma-subunit Binding Dark Adaptation Lysobisphosphatidic Acid Metabolic Process Light Adaption Regulation Of Locomotion Involved In Locomotory Behavior Acid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip
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