PCBP1 and NOVA1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PCBP1	NOVA1
Description		poly(rC) binding protein 1	NOVA alternative splicing regulator 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Nuclear Speck Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Cadherin Binding Sequence-specific Single Stranded DNA Binding	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Sequence-specific MRNA Binding
	Biological Process	Viral RNA Genome Replication Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing Nervous System Development RNA Splicing Regulation Of RNA Metabolic Process Negative Regulation Of Cold-induced Thermogenesis
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Male-pattern baldness ( 28196072)	BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophilic esophagitis ( 25407941) Finger osteoarthritis severity (hand Klsum) ( 33055079) Hand grip strength ( 29691431) Metabolite levels ( 23823483) Migraine ( 27182965) Neuritic plaque ( 31497858) Overweight status ( 25133637) Peanut allergy ( 29030101) Plasma anti-thyroid peroxidase levels ( 29678681) Zinc levels ( 26025379)
Interacting Genes		57 interacting genes: ANP32A APP ARIH1 BCL2L13 CAV3 CELF2 CELF3 DARS1-AS1 ERG EWSR1 FTH1 GNB2 HMGA1 HMGB2 HNRNPD HNRNPK HNRNPLL HSPA13 HYPK IGF2BP3 KLF1 LMNA MATR3 MOGS NOVA1 OGT PABPC1 PCBP2 PCBP4 PDLIM7 PPIG PPIL3 PRPF3 PTBP1 PUF60 QKI RALY RBFOX2 RBM10 RBM11 RBM14 RBM3 RBM42 RBPMS2 SIVA1 SNCG SNRPA SRPK2 SRSF3 TCERG1 TLE5 TNFAIP3 TSC22D4 UGP2 ZCCHC10 ZNF384 ZNF830	6 interacting genes: APP PCBP1 RNF10 RPP14 SMARCC2 SRPK1
Entrez ID		5093	4857
HPRD ID		03128	03693
Ensembl ID		ENSG00000169564	ENSG00000139910
Uniprot IDs		Q15365 Q53SS8	B7Z770 P51513
PDB IDs		1WVN 1ZTG 3VKE	1DT4 2ANN 2ANR
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing RNA Splicing MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Metabolic Process RNA Processing MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleus MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Pre-mRNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Speck MRNA Stabilization Negative Regulation Of Gene Expression MRNA 3'-UTR Binding CRD-mediated MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Sequence-specific Single Stranded DNA Binding Nuclear Matrix Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Endoribonuclease Complex Ribonuclease P Complex Regulation Of Spontaneous Synaptic Transmission Chromatin Organization NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Axon Choice Point Recognition Regulation Of Nucleobase-containing Compound Metabolic Process Viral RNA Genome Replication Nucleus Heparan Sulfate Binding Signaling Receptor Activator Activity
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