RABGEF1 and TXN2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RABGEF1	TXN2
Description		RAB guanine nucleotide exchange factor 1	thioredoxin 2
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Dendrite Early Endosome Membrane Vesicle Recycling Endosome Presynaptic Endosome	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein-disulfide Reductase Activity
	Biological Process	Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Ras Protein Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Negative Regulation Of Interleukin-6 Production Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Activation Kit Signaling Pathway Mast Cell Degranulation Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mast Cell Migration Dendritic Transport Negative Regulation Of Kit Signaling Pathway	Cell Redox Homeostasis
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs	Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 29760442 32528159)
Interacting Genes		49 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	79 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B CSTPP1 DCTD DDIT3 ETHE1 FAM9B FHL5 GOLGA6L9 GPRASP2 GPRASP3 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SUN2 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32
Entrez ID		27342	25828
HPRD ID		11477	07161
Ensembl ID		ENSG00000154710	ENSG00000100348
Uniprot IDs		A8K3R3 B3KMF1 Q9UJ41	Q99757
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U	1UVZ 1W4V 1W89
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Protein Binding Adipose Tissue Development Protein Tag Activity BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Ubiquitin Protein Ligase Binding Recycling Endosome Connective Tissue Development Endosome Protein Ubiquitination Cellular Localization Ubiquitin Protein Ligase Activity Mon1-Ccz1 Complex Vacuolar Transport Organelle Transport Along Microtubule Protein Modification By Small Protein Conjugation Cytoplasm Vesicle-mediated Transport In Synapse Melanosome Organization Vesicle Endosome Membrane Post-Golgi Vesicle-mediated Transport Pigment Granule Organization Modification-dependent Protein Catabolic Process Ubiquitin Binding Protein Localization To Ciliary Membrane Regulation Of Lysosome Size BORC Complex Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Microvesicle Protein Targeting Early Endosome Endosome To Melanosome Transport Fat Pad Development Regulation Of Endosome Size Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Post-translational Protein Modification Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Side Of Lysosomal Membrane Proteolysis Involved In Protein Catabolic Process Golgi To Plasma Membrane Transport Intracellular Protein Transport Secretion By Cell	Identical Protein Binding Protein Binding Microtubule Organizing Center Organelle Organization Cytoskeleton Organization Cytoskeleton Membraneless Organelle Assembly Spindle Assembly Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Synaptonemal Complex Microtubule Cytoskeleton Organization Cytoplasm Microtubule-based Process
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