PRPF19 and RPA1

Number of citations of the paper that reports this interaction (PubMedID 28666352)
77

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, biochemical)

		PRPF19	RPA1
Description		pre-mRNA processing factor 19	replication protein A1
Image
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Lipid Droplet Spindle Cytoskeleton Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nuclear Chromosome Chromosome, Telomeric Region Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-rich Strand Telomeric DNA Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Damage Checkpoint Signaling Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining MRNA Processing DNA Damage Response Intracellular Protein Localization RNA Splicing Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of MRNA Splicing, Via Spliceosome Protein K63-linked Ubiquitination	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination Chromatin Organization DNA Damage Response Telomere Maintenance Via Telomerase Positive Regulation Of Cell Population Proliferation Hemopoiesis Protein Localization To Chromosome Homeostasis Of Number Of Cells Within A Tissue Chromosome Organization Meiotic Cell Cycle Protein Localization To Site Of Double-strand Break
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS			Airway imaging phenotypes ( 26030696) Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		24 interacting genes: CEBPA CTBP1 DDX42 DNTT EGLN3 ESR1 EXOC7 GATA4 GSTK1 HSPB1 MYL9 OGT POLR2A PSMB4 PTEN RBFOX2 RPA1 RPA3 SETMAR SMNDC1 U2AF1 UBE2D3 USP7 VPS35	70 interacting genes: AICDA AJUBA AKTIP ASCC2 ATM ATR BLM BRCA2 BRIP1 CCNA1 CEBPA CPE CSNK2B DMC1 EHMT2 ERCC1 ERCC4 GNB5 GRB2 HAX1 HELB HGH1 HIRA HNRNPUL1 HSPA6 HUS1 KAT2A KAT2B MCM2 MCM7 MMS22L MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRIMPOL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RECQL RFWD3 RIPK1 RNF20 RNF40 RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SEM1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WAS WRN XPA XPC ZBTB14
Entrez ID		27339	6117
HPRD ID		12214	01565
Ensembl ID		ENSG00000110107	ENSG00000132383
Uniprot IDs		Q9UMS4	P27694
PDB IDs		4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N 5EAY 5N85 5N8A 7XUT 7XUV 7XUW 7XV0 7XV1 7XV4 8JZV 8JZY 8K00 8RK2 9J1S 9MJ5
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Binding Nucleic Acid Binding Cajal Body RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Autophagy DNA Replication Factor A Complex White Fat Cell Differentiation Double-strand Break Repair Site Of Double-strand Break Response To Stress DNA Metabolic Process Rhythmic Process Estrogen Receptor Signaling Pathway PML Body Single-stranded DNA Binding Negative Regulation Of Protein Catabolic Process Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Nutrient Condensed Chromosome Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA Nucleotidylexotransferase Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Terminal Button Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Proteolysis Negative Regulation Of Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Carbohydrate Homeostasis	DNA Metabolic Process DNA Repair DNA Damage Response DNA Recombination Cellular Response To Stress Double-strand Break Repair Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction In Response To DNA Damage Macromolecule Metabolic Process Single-stranded DNA Binding Cellular Response To Radiation Nucleoplasm DNA Replication Nucleotide-excision Repair DNA Damage Checkpoint Signaling Response To Ionizing Radiation Response To Radiation Site Of Double-strand Break Replication Fork Processing Chromosome, Telomeric Region Chromosome Organization Cellular Response To Ionizing Radiation Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Telomere Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Mismatch Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Response To UV Regulation Of Cellular Response To Stress DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding DNA Replication Factor A Complex MutLalpha Complex Binding Response To Gamma Radiation Mitotic Recombination DNA Helicase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?