PRPF19 and VPS35

Number of citations of the paper that reports this interaction (PubMedID 33305682)
68

Data Source:
BioGRID (unspecified method)

		PRPF19	VPS35
Description		pre-mRNA processing factor 19	VPS35 retromer complex component
Image
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Lipid Droplet Spindle Cytoskeleton Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Membrane Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding D1 Dopamine Receptor Binding
	Biological Process	DNA Damage Checkpoint Signaling Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining MRNA Processing DNA Damage Response Intracellular Protein Localization RNA Splicing Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of MRNA Splicing, Via Spliceosome Protein K63-linked Ubiquitination	Intracellular Protein Transport Lysosome Organization Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Protein Transport Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Negative Regulation Of Protein Homooligomerization Protein Localization To Organelle Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Regulation Of Protein Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Voluntary Musculoskeletal Movement Regulation Of Transport Regulation Of Protein Metabolic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Wnt Protein Secretion Regulation Of Synapse Maturation Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Postsynapse Organization Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Regulation Of Postsynapse Assembly Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Regulation Of Terminal Button Organization
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Interacting Genes		24 interacting genes: CEBPA CTBP1 DDX42 DNTT EGLN3 ESR1 EXOC7 GATA4 GSTK1 HSPB1 MYL9 OGT POLR2A PSMB4 PTEN RBFOX2 RPA1 RPA3 SETMAR SMNDC1 U2AF1 UBE2D3 USP7 VPS35	15 interacting genes: APP DRD1 FILNC1 GNL1 LINC01554 MTNR1B PRPF19 SLC11A2 SNX1 USP7 VEGFA VPS26B VPS29 YBX1 ZNF512B
Entrez ID		27339	55737
HPRD ID		12214	06085
Ensembl ID		ENSG00000110107	ENSG00000069329
Uniprot IDs		Q9UMS4	Q96QK1
PDB IDs		4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI 7BLN 7BLO 8R02 8R0J 8RKS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Binding Nucleic Acid Binding Cajal Body RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Autophagy DNA Replication Factor A Complex White Fat Cell Differentiation Double-strand Break Repair Site Of Double-strand Break Response To Stress DNA Metabolic Process Rhythmic Process Estrogen Receptor Signaling Pathway PML Body Single-stranded DNA Binding Negative Regulation Of Protein Catabolic Process Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Nutrient Condensed Chromosome Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA Nucleotidylexotransferase Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Terminal Button Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Proteolysis Negative Regulation Of Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Carbohydrate Homeostasis	Negative Regulation Of MiRNA Transcription Retromer Complex Retromer, Cargo-selective Complex Early Endosome Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Retrograde Transport, Endosome To Golgi Mating Behavior Cellular Response To Catecholamine Stimulus Regulation Of Neurotransmitter Uptake Response To Catecholamine Insulin Receptor Binding Cytosolic Transport Positive Regulation Of Receptor Internalization Blood Vessel Diameter Maintenance Regulation Of Tube Size Late Endosome Endosome Chemoattractant Activity Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Chemotaxis Regulation Of Protein Localization Nickel Cation Transmembrane Transporter Activity Nickel Cation Transmembrane Transport Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Visual Learning Positive Regulation Of Receptor-mediated Endocytosis Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Protein Transport Acetylcholine Receptor Activator Activity Cell Projection Morphogenesis Myeloid Cell Development Visual Behavior Learning Or Memory Platelet Alpha Granule Lumen
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