PRPF19 and DNTT

Number of citations of the paper that reports this interaction (PubMedID 12960389)
26

Data Source:
HPRD (in vitro, in vivo)

		PRPF19	DNTT
Description		pre-mRNA processing factor 19	DNA nucleotidylexotransferase
Image
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Lipid Droplet Spindle Cytoskeleton Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Chromatin Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	DNA Binding DNA-directed DNA Polymerase Activity DNA Nucleotidylexotransferase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Damage Checkpoint Signaling Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining MRNA Processing DNA Damage Response Intracellular Protein Localization RNA Splicing Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of MRNA Splicing, Via Spliceosome Protein K63-linked Ubiquitination	DNA Metabolic Process DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Response To ATP DNA Biosynthetic Process
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs			2',3'-Dideoxyadenosine triphosphate
Diseases
GWAS
Interacting Genes		24 interacting genes: CEBPA CTBP1 DDX42 DNTT EGLN3 ESR1 EXOC7 GATA4 GSTK1 HSPB1 MYL9 OGT POLR2A PSMB4 PTEN RBFOX2 RPA1 RPA3 SETMAR SMNDC1 U2AF1 UBE2D3 USP7 VPS35	10 interacting genes: ABTB2 DNTTIP1 DNTTIP2 MEI4 PCNA PRPF19 REL TCF4 TLL2 XRCC6
Entrez ID		27339	1791
HPRD ID		12214	08925
Ensembl ID		ENSG00000110107	ENSG00000107447
Uniprot IDs		Q9UMS4	P04053
PDB IDs		4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	2COE 5W4E
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Binding Nucleic Acid Binding Cajal Body RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Autophagy DNA Replication Factor A Complex White Fat Cell Differentiation Double-strand Break Repair Site Of Double-strand Break Response To Stress DNA Metabolic Process Rhythmic Process Estrogen Receptor Signaling Pathway PML Body Single-stranded DNA Binding Negative Regulation Of Protein Catabolic Process Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Nutrient Condensed Chromosome Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA Nucleotidylexotransferase Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Terminal Button Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Proteolysis Negative Regulation Of Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Carbohydrate Homeostasis	Damaged DNA Binding DNA End Binding DNA Metabolic Process Telomere Maintenance Chromosome Organization Double-strand Break Repair Via Nonhomologous End Joining Ku70:Ku80 Complex Chromosome PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Beta-catenin-TCF7L2 Complex Negative Regulation Of Skeletal Muscle Tissue Growth
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