GPKOW and GMPPA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPKOW	GMPPA
Description		G-patch domain and KOW motifs	GDP-mannose pyrophosphorylase A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex	Cytoplasm Cytosol Extracellular Exosome GDP-mannose Pyrophosphorylase Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Mannose-1-phosphate Guanylyltransferase (GTP) Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Enzyme Binding Molecular Sensor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Protein Glycosylation Glycoprotein Metabolic Process GDP-mannose Biosynthetic Process Negative Regulation Of Biosynthetic Process GDP-mannose Metabolic Process Telencephalon Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Muscle Organ Morphogenesis Cognition Neuromuscular Process Neuron Apoptotic Process Skeletal Muscle Organ Development Motor Behavior Negative Regulation Of Small Molecule Metabolic Process
Pathways		mRNA Splicing - Major Pathway	Synthesis of GDP-mannose
Drugs
Diseases
GWAS
Interacting Genes		47 interacting genes: APP ARMCX1 BUD13 CCDC57 CNKSR3 DDIT4L EFHC2 FBXO7 GMPPA GOLGA2 GSTM5 HOOK2 HSF2BP IKBKG KANK2 LNX1 LRP2BP LZTS1 MAD1L1 MEOX2 MESD MID2 MTUS2 NINL OGT PHF1 PIBF1 PICK1 POLR2G PPP1CA PRKAR1B PRPF4 PRPF8 REL ROPN1 SH3GL1 SORBS3 SPDYE4 TCEA1 TCEA2 TRAF2 TRIM23 TRIM27 VPS52 WDR77 WDR83 ZMYND12	11 interacting genes: AKT1 BTC CDR2 CRP DCUN1D1 GMPPB GPKOW LSM8 NCK1 PNKD ZNF688
Entrez ID		27238	29926
HPRD ID		06737	13588
Ensembl ID		ENSG00000068394	ENSG00000144591
Uniprot IDs		Q92917	A0A384MDS7 Q96IJ6
PDB IDs		7DVQ 7QTT 8CH6	7D72 7D73 7D74
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Binding Identical Protein Binding Regulation Of Autophagy Positive Regulation Of Autophagy	Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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