TUBGCP4 and RNF146

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TUBGCP4	RNF146
Description		tubulin gamma complex component 4	ring finger protein 146
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GO Annotations	Cellular Component	Spindle Pole Gamma-tubulin Complex Gamma-tubulin Ring Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Recycling Endosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Gamma-tubulin Binding Microtubule Minus-end Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle Protein-containing Complex Assembly	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Glycine levels ( 30837465) HDL cholesterol ( 30275531) Liver enzyme levels (alkaline phosphatase) ( 33972514) Triglycerides ( 30275531)	Breast cancer ( 18326623) Diverticular disease ( 30177863) Food addiction ( 27106561) Intracranial volume ( 22504418) LDL cholesterol levels in HIV infection ( 33109212) Subcortical brain region volumes ( 25607358) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		33 interacting genes: ADAMTSL4 ADD3 AP2B1 CBY2 CCDC85B CHIC2 DGCR6 EFHC2 FBF1 FDXACB1 GFAP GLYCTK GOLGA2 KCTD17 KRT15 KRT18 KRT4 KRT6B LZTR1 MAD1L1 NUDT3 PAK5 PHKA1 RNF146 RPRD1B SDSL STN1 TRIM27 TRIM55 TRIM63 TUBG1 USHBP1 VIM	12 interacting genes: KASH5 NDUFAF3 PFN2 TGFBR1 TNKS TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		27229	81847
HPRD ID		10616	11511
Ensembl ID		ENSG00000137822	ENSG00000118518
Uniprot IDs		Q9UGJ1	Q9NTX7
PDB IDs		3RIP 6V69 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VRD 8VRJ 8VRK	2D8T 3V3L 6CF6
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Cytoskeleton Intermediate Filament Organization Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Cytoskeleton Organization Supramolecular Fiber Organization Cytoskeleton Identical Protein Binding Bergmann Glial Cell Differentiation Structural Constituent Of Skin Epidermis Scaffold Protein Binding Microtubule Astrocyte Development	Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Chromosome, Telomeric Region Ubiquitin-protein Transferase Activity Protein Ubiquitination Regulation Of Telomere Capping Spindle Assembly Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Spindle Organization Negative Regulation Of Telomere Maintenance Protein Modification Process Peptidyl-serine Phosphorylation Double-strand Break Repair Positive Regulation Of Protein Phosphorylation DNA Recombination Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Stress Fiber Assembly TORC2 Complex Disassembly Oxidized DNA Binding Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Protein Modification Process Positive Regulation Of Actin Filament Bundle Assembly Membraneless Organelle Assembly Damaged DNA Binding Positive Regulation Of Phosphate Metabolic Process Macromolecule Metabolic Process Chromosome Vascular Endothelial Cell Proliferation Epicardium Morphogenesis TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Autoubiquitination Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Chromosome Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Meiotic Spindle Pole Chromosome Organization ATP Binding Positive Regulation Of Protein Modification Process DNA End Binding Telomere Maintenance Regulation Of Protein Phosphorylation Ku70:Ku80 Complex Regulation Of Stress Fiber Assembly Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis
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