PPP3CC and ENTPD4

		PPP3CC	ENTPD4
Description		protein phosphatase 3 catalytic subunit gamma	ectonucleoside triphosphate diphosphohydrolase 4
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Protein Serine/threonine Phosphatase Complex Presynapse Glutamatergic Synapse	Golgi Membrane Autophagosome Membrane Lysosome Lysosomal Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding	GTPase Activity GDP Phosphatase Activity Protein Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Ribonucleoside Triphosphate Phosphatase Activity CDP Phosphatase Activity CTPase Activity UDP Phosphatase Activity
	Biological Process	Protein Dephosphorylation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane	UDP Catabolic Process Purine Ribonucleotide Metabolic Process Pyrimidine Ribonucleotide Catabolic Process Nucleobase-containing Small Molecule Catabolic Process CTP Metabolic Process GDP Catabolic Process
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events	Phosphate bond hydrolysis by NTPDase proteins
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)	Birth weight ( 31043758) Height ( 31562340) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		18 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B ENTPD4 GFRA2 HAX1 ITPKC LEPROTL1 PPP3R1 SDC2 SLC18A1 SORBS3 TGFBR1 THAP7 UNC119	2 interacting genes: PPP3CC RPS27
Entrez ID		5533	9583
HPRD ID		00236	09618
Ensembl ID		ENSG00000120910	ENSG00000197217
Uniprot IDs		P48454	Q9Y227
PDB IDs		7U0T	6WG5
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Heparan Sulfate Binding Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Transmembrane Receptor Protein Serine/threonine Kinase Activity Cytoplasmic Vesicle Synapse Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Regulation Of Cellular Component Organization PTB Domain Binding Cell Projection Morphogenesis Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import System Development Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Positive Regulation Of Calcium-mediated Signaling Regulation Of Signal Transduction Regulation Of Multicellular Organism Growth Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Lipoprotein Particle Positive Regulation Of Cell Differentiation Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Synaptic Vesicle Recycling Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Serine/threonine Phosphatase Complex Presynapse Positive Regulation Of Calcium Ion Import Across Plasma Membrane Calmodulin-dependent Protein Phosphatase Activity Glutamatergic Synapse Calcineurin Complex Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Ribosomal Small Subunit Assembly Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Recycling Regulation Of Calcineurin-mediated Signaling Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Cytosolic Small Ribosomal Subunit Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transport Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Small-subunit Processome Ribosomal Small Subunit Biogenesis Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Calcium-mediated Signaling Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Calcium Ion Transport Cytosolic Ribosome GABA-ergic Synapse Negative Regulation Of Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Cytoplasmic Translation Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Calcium Ion Transmembrane Transport Structural Constituent Of Ribosome
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