GDNF and GFRA1

Number of citations of the paper that reports this interaction (PubMedID 8674117)
0

Data Source:
HPRD (in vitro, in vivo)

		GDNF	GFRA1
Description		glial cell derived neurotrophic factor	GDNF family receptor alpha 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus	Extracellular Space Endosome Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Axon Neuronal Cell Body Receptor Complex Extracellular Exosome Side Of Membrane Plasma Membrane Protein Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Protein Homodimerization Activity Chemoattractant Activity Involved In Axon Guidance	Neurotrophin Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Peripheral Nervous System Development Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Tissue Development Regulation Of Gene Expression Dorsal Spinal Cord Development Postganglionic Parasympathetic Fiber Development Neuron Differentiation Peristalsis Neuron Projection Development Positive Regulation Of Dopamine Secretion Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Animal Organ Development Embryonic Organ Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Chemoattraction Of Axon Commissural Neuron Axon Guidance Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Semaphorin-plexin Signaling Pathway	Kidney Development Cell Surface Receptor Signaling Pathway Nervous System Development Male Gonad Development Cell Migration Neuron Differentiation Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud	NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud
Drugs		Chondroitin sulfate
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD)
GWAS		Asthma ( 29273806) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Major depressive disorder ( 20125088)	Blood protein levels ( 30072576) Delirium ( 29631748) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061) Migraine without aura ( 28952330) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)
Interacting Genes		8 interacting genes: AGTRAP GFRA1 GFRA2 MUC1 NCAM1 RET SCAMP5 SYP	5 interacting genes: GDNF NCAM1 NRTN RET SOCS3
Entrez ID		2668	2674
HPRD ID		02906	03291
Ensembl ID		ENSG00000168621	ENSG00000151892
Uniprot IDs		A0A0S2Z3T2 A0A0S2Z3V2 P39905	B7Z856 P56159
PDB IDs		2V5E 3FUB 4UX8 6Q2N	6Q2N
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Activity Side Of Membrane Plasma Membrane Protein Complex Extrinsic Component Of Membrane Receptor Complex Signaling Receptor Activity Regulation Of Cell Adhesion Mediated By Integrin External Side Of Plasma Membrane Plasma Membrane Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Regulation Of Semaphorin-plexin Signaling Pathway Posterior Midgut Development Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Regulation Of Opioid Receptor Signaling Pathway Nervous System Development Neurotrophin Receptor Activity Ureter Maturation Synaptic Vesicle Membrane Angiotensin Type II Receptor Activity GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development Kidney Development Enzyme-linked Receptor Protein Signaling Pathway Golgi Membrane Heparan Sulfate Binding Synaptic Vesicle Maturation Endosome Developmental Maturation Lymphocyte Migration Into Lymphoid Organs Axon Guidance Neuron Projection Guidance Positive Regulation Of Kidney Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Synaptic Vesicle Priming Positive Regulation Of Cell Size Enteric Nervous System Development Cytoplasmic Vesicle Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Transcription By Competitive Promoter Binding Commissural Neuron Axon Guidance Regulation Of Short-term Neuronal Synaptic Plasticity	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Binding Neural Crest Cell Migration Regulation Of Semaphorin-plexin Signaling Pathway Mesenchymal Cell Migration Neuron Projection Development Ameboidal-type Cell Migration Enteric Nervous System Development Commissural Neuron Axon Guidance Embryonic Epithelial Tube Formation Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Epithelial Tube Formation Metanephros Development Regulation Of Kidney Development Ureteric Bud Development Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesonephric Epithelium Development Mesonephric Tubule Development Cell Projection Organization Receptor Tyrosine Kinase Binding Tissue Morphogenesis Kidney Epithelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Tube Formation Posterior Midgut Development Morphogenesis Of A Branching Structure Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Factor Activity Morphogenesis Of A Branching Epithelium Cell Surface Receptor Signaling Pathway Chemoattraction Of Axon Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Kidney Development Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Ureter Maturation Autonomic Nervous System Development Ureteric Bud Formation Cell Migration Dorsal Spinal Cord Development GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development
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