QPCT and CFLAR

		QPCT	CFLAR
Description		glutaminyl-peptide cyclotransferase	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Extracellular Region Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Binding Zinc Ion Binding Glutaminyl-peptide Cyclotransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding
	Biological Process	Peptidyl-pyroglutamic Acid Biosynthetic Process, Using Glutaminyl-peptide Cyclotransferase Protein Modification Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Neutrophil degranulation	TRAIL signaling
Drugs		1-benzylimidazole N-acetylhistamine Glutamine t-butyl ester
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 24292274 26956414 28165464) HDL cholesterol levels in HIV infection ( 33109212) Height ( 31562340) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Schizophrenia ( 23974872 30285260)	Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)
Interacting Genes		3 interacting genes: CFLAR HRAS UBQLN2	49 interacting genes: ATF2 BCL2L1 CAB39 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CD28 CRYGA CUL1 DAXX DEDD DEDD2 ECE1 EEF1B2 FADD FGF13 FZD5 GAPDHS GJA1 IKBKB KCNIP3 MAP2K4 MAP2K7 MEX3B MYL1 NDUFS1 NEURL3 NFKB1 PROC PSEN2 QPCT RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8
Entrez ID		25797	8837
HPRD ID		06140	04671
Ensembl ID		ENSG00000115828	ENSG00000003402
Uniprot IDs		Q16769	A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		2AFM 2AFO 2AFS 2AFU 2AFW 2AFX 2AFZ 2ZED 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP 3PBB 3PBE 3SI0 4YU9 4YWY 6GBX 6YI1 6YJY 7CM0 7COZ 7CP0 7D8E 8HY3 8XGB 8XGT 8XGY 9ISD 9IVV	2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Epithelial Cell Proliferation Phospholipase C Activator Activity Regulation Of ERK1 And ERK2 Cascade Oncogene-induced Cell Senescence Regulation Of Neuron Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade GTPase Complex Ripoptosome Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Striated Muscle Atrophy Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Cell Projection Organization Regulation Of Epithelial Cell Proliferation T-helper 1 Type Immune Response Muscle Atrophy Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Ruffle Assembly Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Schwann Cell Development Response To Nitric Oxide Regulation Of Myoblast Fusion Skeletal Muscle Tissue Regeneration Regulation Of Protein Targeting To Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Tissue Development	Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production
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