SH3BP4 and MRGBP

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		SH3BP4	MRGBP
Description		SH3 domain binding protein 4	MRG domain binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Extracellular Exosome	Nucleosome Nucleus Nucleoplasm NuA4 Histone Acetyltransferase Complex H4/H2A Histone Acetyltransferase Complex
	Molecular Function	GDP-dissociation Inhibitor Activity Protein Binding Small GTPase Binding Identical Protein Binding	Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Amino acids regulate mTORC1	HATs acetylate histones
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Obstetric antiphospholipid syndrome ( 28424481) Orofacial clefts ( 22419666) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		24 interacting genes: AMT CCT3 CEP78 CFTR CIMIP6 CIZ1 DNAJA4 EPS15 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 SNCA TCP1 TTC1 TXNL1 YWHAG ZBTB37	25 interacting genes: ACTB ACTL6A BRD8 DAPK1 DMAP1 HSPB1 ING1 KRTAP1-1 KRTAP10-7 KRTAP17-1 KRTAP5-7 LRRK2 MEAF6 MFHAS1 MORF4L1 MORF4L2 MSL1 NBPF19 NOTCH2NLA RUVBL1 SH3BP4 TRRAP TUBB VAV2 YEATS4
Entrez ID		23677	55257
HPRD ID		09285	16646
Ensembl ID		ENSG00000130147	ENSG00000101189
Uniprot IDs		Q9P0V3	Q9NV56
PDB IDs			2N1D
Enriched GO Terms of Interacting Partners?		Protein Folding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone Cytosol Protein Folding Chaperone Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Heat Shock Protein Binding Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Receptor Recycling Negative Regulation Of Microtubule Polymerization Protein-folding Chaperone Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Receptor Recycling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Refolding Regulation Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Steroid Hormone Receptor Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Phosphoprotein Binding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Binding Of Sperm To Zona Pellucida Sperm-egg Recognition H4/H2A Histone Acetyltransferase Complex ATP Hydrolysis Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Maintenance Of Protein Localization In Organelle Regulation Of Protein Stability Protein Sequestering Activity Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process	NuA4 Histone Acetyltransferase Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Nucleosome Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of DNA Metabolic Process Swr1 Complex Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Matrix Positive Regulation Of Stem Cell Population Maintenance Intermediate Filament Regulation Of Stem Cell Population Maintenance Brahma Complex NpBAF Complex GBAF Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage RSC-type Complex Ino80 Complex Negative Regulation Of GTPase Activity Regulation Of DNA Strand Elongation Syntaxin-1 Binding Structural Constituent Of Cytoskeleton Sin3-type Complex Regulation Of Synaptic Vesicle Endocytosis Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of DNA Replication Regulation Of RNA Biosynthetic Process DNA Repair Regulation Of Nucleotide-excision Repair Regulation Of Macromolecule Biosynthetic Process
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