SH3BP4 and CEP78

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		SH3BP4	CEP78
Description		SH3 domain binding protein 4	centrosomal protein 78
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Extracellular Exosome	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection
	Molecular Function	GDP-dissociation Inhibitor Activity Protein Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus	Cell Projection Organization Flagellated Sperm Motility Negative Regulation Of Protein Ubiquitination Cilium Organization Protein Localization To Cilium Protein Localization To Centrosome
Pathways		Amino acids regulate mTORC1	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Obstetric antiphospholipid syndrome ( 28424481) Orofacial clefts ( 22419666) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		24 interacting genes: AMT CCT3 CEP78 CFTR CIMIP6 CIZ1 DNAJA4 EPS15 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 SNCA TCP1 TTC1 TXNL1 YWHAG ZBTB37	3 interacting genes: HSPB1 SH3BP4 UBC
Entrez ID		23677	84131
HPRD ID		09285	19359
Ensembl ID		ENSG00000130147	ENSG00000148019
Uniprot IDs		Q9P0V3	A0A2R8YCP0 A8MST6 Q5JTW2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Folding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone Cytosol Protein Folding Chaperone Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Heat Shock Protein Binding Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Receptor Recycling Negative Regulation Of Microtubule Polymerization Protein-folding Chaperone Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Receptor Recycling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Refolding Regulation Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Steroid Hormone Receptor Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Phosphoprotein Binding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Binding Of Sperm To Zona Pellucida Sperm-egg Recognition H4/H2A Histone Acetyltransferase Complex ATP Hydrolysis Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Maintenance Of Protein Localization In Organelle Regulation Of Protein Stability Protein Sequestering Activity Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process	Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Negative Regulation Of Protein Kinase C Signaling Extracellular Exosome Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Regulation Of Autophagy Protein Tag Activity Amino Acid Import GDP-dissociation Inhibitor Activity Negative Regulation Of GTPase Activity
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