PDE6G

Description		phosphodiesterase 6G
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GO Annotations	Cellular Component	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Visual Perception Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs		Sildenafil Tadalafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases		Retinitis pigmentosa (RP)
GWAS		Blond vs. brown/black hair color ( 30531825) High myopia ( 31816047) Refractive error ( 32231278)
Novel Interacting Genes		12 novel interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 PRKAB2 SLC27A2 SRC TRIP10
Interacting Genes		12 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 PRKAB2 SLC27A2 SRC TRIP10
Entrez ID		5148
HPRD ID		08914
Ensembl ID		ENSG00000185527
Uniprot IDs		P18545
PDB IDs		3JWR
Enriched GO Terms of Interacting Partners?		Import Into Cell Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Receptor Internalization ERBB Signaling Pathway Vesicle-mediated Transport Actin Cytoskeleton Organization Schwann Cell Development Regulation Of Early Endosome To Late Endosome Transport Contractile Actin Filament Bundle Assembly Stress Fiber Assembly ERBB2 Signaling Pathway Actin Filament-based Process Phagocytic Cup Ephrin Receptor Binding Receptor-mediated Endocytosis Cell Cortex Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Heart Contraction Signal Transduction Podosome Negative Regulation Of Immune Response Protein Domain Specific Binding T Cell Costimulation Phosphotyrosine Residue Binding Nucleotide Binding Peptidyl-tyrosine Phosphorylation Plasma Membrane Negative Regulation Of Relaxation Of Smooth Muscle Regulation Of Blood Circulation Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Guanyl-nucleotide Exchange Factor Adaptor Activity Cellular Response To Nutrient Levels Actin Filament Bundle Assembly Glial Cell Development TORC1 Signaling Actin Filament Bundle Organization Negative Regulation Of TORC1 Signaling Autophagy Clathrin-coated Pit Caveola Edg-2 Lysophosphatidic Acid Receptor Binding Negative Regulation Of Membrane Tubulation Vesicle Scission Mu-type Opioid Receptor Binding Insulin Receptor Signaling Pathway Grb2-EGFR Complex Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity
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