RAB3GAP1 and WDR7

Number of citations of the paper that reports this interaction (PubMedID 12786944)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAB3GAP1	WDR7
Description		RAB3 GTPase activating protein catalytic subunit 1	WD repeat domain 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Brain Development Hypothalamus Development Rab Protein Signal Transduction Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly	Hematopoietic Progenitor Cell Differentiation
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Body mass index ( 25673413) Cholesterol, total ( 20686565 24097068 25961943) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)	Congenital heart disease (septal defects) ( 33201861) Depression and alcohol dependence ( 22064162) Femur bone mineral density x serum urate levels interaction ( 34046847) Multiple sclerosis (age of onset) ( 19010793) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 30297969)
Interacting Genes		8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7	3 interacting genes: FRMD6 RAB27B RAB3GAP1
Entrez ID		22930	23335
HPRD ID		16002	10306
Ensembl ID		ENSG00000115839	ENSG00000091157
Uniprot IDs		A0A8J9AUI2 B9A6J2 Q15042	Q9Y4E6
PDB IDs		8VYB
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagosome Assembly Regulation Of Vacuole Organization Autolysosome Membrane Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Rab Protein Signal Transduction Protein Transport Regulation Of Macroautophagy Establishment Of Protein Localization Negative Regulation Of Macroautophagy Regulation Of Organelle Assembly Autophagy Cytoplasmic Vesicle GTPase Activity Intracellular Protein Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion GTP Binding G Protein Activity Phagocytic Vesicle Membrane Phagocytic Vesicle Negative Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Intracellular Protein Transport Positive Regulation Of Protein Lipidation Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Protein Lipidation Phagosome Acidification Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Lipoprotein Metabolic Process Small GTPase-mediated Signal Transduction Autophagosome-lysosome Fusion Phagosome-lysosome Fusion Small GTPase Binding Myosin V Binding Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle Size Vesicle Organization Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Autophagosome Assembly	Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Protein Lipidation Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cytoplasmic Side Of Apical Plasma Membrane Apical Constriction Positive Regulation Of Secretion Platelet Dense Granule Membrane Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Anterograde Axonal Protein Transport Positive Regulation Of Glutamate Secretion Protein Transport Along Microtubule Regulation Of Lipoprotein Metabolic Process Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity Trans-Golgi Network Transport Vesicle Myosin V Binding Zymogen Granule Membrane Regulation Of Vesicle-mediated Transport Rab Protein Signal Transduction Regulation Of Secretion By Cell Positive Regulation Of Neurotransmitter Secretion Regulation Of Glutamate Secretion Positive Regulation Of Hippo Signaling Regulation Of Secretion Positive Regulation Of Amino Acid Transport Endoplasmic Reticulum Tubular Network Positive Regulation Of Autophagosome Assembly Exocytic Vesicle Multivesicular Body Membrane Positive Regulation Of Vacuole Organization Apical Junction Complex Face Morphogenesis Positive Regulation Of Synaptic Transmission, Glutamatergic Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Transport Synaptic Vesicle Endocytosis Golgi Stack Lipid Droplet Organization Actin-mediated Cell Contraction Regulation Of Calcium Ion-dependent Exocytosis Presynaptic Endocytosis Anterograde Axonal Transport Multivesicular Body Sorting Pathway
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