WDR7 and RAB27B

		WDR7	RAB27B
Description		WD repeat domain 7	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function		Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways			Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Congenital heart disease (septal defects) ( 33201861) Depression and alcohol dependence ( 22064162) Femur bone mineral density x serum urate levels interaction ( 34046847) Multiple sclerosis (age of onset) ( 19010793) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 30297969)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		3 interacting genes: FRMD6 RAB27B RAB3GAP1	18 interacting genes: CNPY2 DHPS EFHD1 GORASP2 MEX3C MLPH MYRIP NR2E1 RPH3A RPH3AL SEC11A STARD6 SYTL1 SYTL2 SYTL4 TUFT1 UNC13D WDR7
Entrez ID		23335	5874
HPRD ID		10306	04846
Ensembl ID		ENSG00000091157	ENSG00000041353
Uniprot IDs		Q9Y4E6	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?		Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Protein Lipidation Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cytoplasmic Side Of Apical Plasma Membrane Apical Constriction Positive Regulation Of Secretion Platelet Dense Granule Membrane Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Anterograde Axonal Protein Transport Positive Regulation Of Glutamate Secretion Protein Transport Along Microtubule Regulation Of Lipoprotein Metabolic Process Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity Trans-Golgi Network Transport Vesicle Myosin V Binding Zymogen Granule Membrane Regulation Of Vesicle-mediated Transport Rab Protein Signal Transduction Regulation Of Secretion By Cell Positive Regulation Of Neurotransmitter Secretion Regulation Of Glutamate Secretion Positive Regulation Of Hippo Signaling Regulation Of Secretion Positive Regulation Of Amino Acid Transport Endoplasmic Reticulum Tubular Network Positive Regulation Of Autophagosome Assembly Exocytic Vesicle Multivesicular Body Membrane Positive Regulation Of Vacuole Organization Apical Junction Complex Face Morphogenesis Positive Regulation Of Synaptic Transmission, Glutamatergic Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Transport Synaptic Vesicle Endocytosis Golgi Stack Lipid Droplet Organization Actin-mediated Cell Contraction Regulation Of Calcium Ion-dependent Exocytosis Presynaptic Endocytosis Anterograde Axonal Transport Multivesicular Body Sorting Pathway	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel
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