RAB3GAP1 and RAB3GAP2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAB3GAP1	RAB3GAP2
Description		RAB3 GTPase activating protein catalytic subunit 1	RAB3 GTPase activating non-catalytic protein subunit 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse	Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex Presynaptic Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Enzyme Activator Activity Enzyme Regulator Activity Small GTPase Binding
	Biological Process	Brain Development Hypothalamus Development Rab Protein Signal Transduction Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly	Intracellular Protein Transport Macroautophagy Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Synaptic Signaling Positive Regulation Of Protein Lipidation Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs	COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	Martsolf syndrome
GWAS		Body mass index ( 25673413) Cholesterol, total ( 20686565 24097068 25961943) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Breast size ( 27182965)
Interacting Genes		8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7	5 interacting genes: CEBPA EXOSC6 FEZ1 RAB3GAP1 UBC
Entrez ID		22930	25782
HPRD ID		16002	11471
Ensembl ID		ENSG00000115839	ENSG00000118873
Uniprot IDs		A0A8J9AUI2 B9A6J2 Q15042	Q9H2M9
PDB IDs		8VYB	8VYB
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagosome Assembly Regulation Of Vacuole Organization Autolysosome Membrane Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Rab Protein Signal Transduction Protein Transport Regulation Of Macroautophagy Establishment Of Protein Localization Negative Regulation Of Macroautophagy Regulation Of Organelle Assembly Autophagy Cytoplasmic Vesicle GTPase Activity Intracellular Protein Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion GTP Binding G Protein Activity Phagocytic Vesicle Membrane Phagocytic Vesicle Negative Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Intracellular Protein Transport Positive Regulation Of Protein Lipidation Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Protein Lipidation Phagosome Acidification Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Lipoprotein Metabolic Process Small GTPase-mediated Signal Transduction Autophagosome-lysosome Fusion Phagosome-lysosome Fusion Small GTPase Binding Myosin V Binding Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle Size Vesicle Organization Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Autophagosome Assembly	RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Vacuole Organization CHOP-C/EBP Complex Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Macroautophagy Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Protein Lipidation Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Response To Phenylpropanoid Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Mitochondrion Organization Urea Cycle Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Fat Cell Proliferation Protein Tag Activity Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Autophagosome Assembly Regulation Of Autophagy Regulation Of Organelle Assembly Rab Protein Signal Transduction Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Glutamate Secretion Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex)
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