TRAK1 and ESS2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		TRAK1	ESS2
Description		trafficking kinesin protein 1	ess-2 spliceosome associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Cell Cortex Membrane Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Axonal Growth Cone Perinuclear Region Of Cytoplasm Axon Cytoplasm	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Myosin Binding TPR Domain Binding GABA Receptor Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport Axonal Transport Of Mitochondrion Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Axonogenesis	MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing
Pathways		Signaling by BRAF and RAF1 fusions RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 28552196) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 32439900) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		17 interacting genes: BLOC1S6 BYSL CDC5L CDK6 ENKD1 ESS2 HGS MAGEB4 OGT POLR2A PRPF6 PTBP1 SKIL SNW1 TRAF3IP1 UTP6 ZNF232	33 interacting genes: ARMC7 CCDC57 CDK5RAP3 CEP55 CPSF7 CRP DGCR6 DHX16 EHMT2 EXOC8 EXOSC7 HOOK1 ITCH KRT31 LYST NEDD4 OGT OIP5 PFDN1 PRPF38B PRRC2B QARS1 RACK1 RBM22 RBM4 SMARCD1 THOC1 TRAK1 TTC14 UTP6 VIM WNK2 YAP1
Entrez ID		22906	8220
HPRD ID		09732	03452
Ensembl ID		ENSG00000182606	ENSG00000100056
Uniprot IDs		A0A087X0N0 A0A0D9SFL5 B7Z218 B7ZAE5 C9JC32 Q9UPV9	F8WEF8 Q96DF8
PDB IDs			8C6J 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Catalytic Step 2 Spliceosome RNA Processing RNA Metabolic Process Spliceosomal Complex RNA Splicing MRNA Metabolic Process Nucleoplasm MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Prp19 Complex Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Binding Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Dentate Gyrus Development Regulation Of Cellular Response To Growth Factor Stimulus U2-type Catalytic Step 2 Spliceosome Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organelle Assembly Maturation Of SSU-rRNA Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Ciliary Base Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin D2-CDK6 Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle SMAD Binding Nucleus Regulation Of Macromolecule Metabolic Process Protein Domain Specific Binding Protein Localization To Lysosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding	RNA Metabolic Process Cyclin Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing Lysosomal Transport Positive Regulation Of Stem Cell Population Maintenance Endosome To Lysosome Transport Vacuolar Transport Negative Regulation Of MAPK Cascade RNA Binding Regulation Of Stem Cell Population Maintenance Spliceosomal Complex Molecular Adaptor Activity Proline-rich Region Binding Regulation Of Macroautophagy Pre-mRNA Binding
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