RHEB and PIGB

		RHEB	PIGB
Description		Ras homolog, mTORC1 binding	phosphatidylinositol glycan anchor biosynthesis class B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Synapse Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding	Alpha-1,2-mannosyltransferase Activity GPI Mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Autophagosome Assembly Cytoplasmic Translation Signal Transduction Small GTPase-mediated Signal Transduction Response To Virus Negative Regulation Of Autophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of TORC1 Signaling Regulation Of Type B Pancreatic Cell Development	GPI Anchor Biosynthetic Process
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes		35 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CENPE CREB3 ECSIT FKBP8 HTT MAPK15 MTOR NCAM1 NOS3 PDE6D PIGB PLD1 PPP1R3C PSEN1 PSEN2 PTPRN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4	2 interacting genes: RHEB SMAD6
Entrez ID		6009	9488
HPRD ID		03188	04988
Ensembl ID		ENSG00000106615	ENSG00000069943
Uniprot IDs		A0A090N900 Q15382	Q92521
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Autophagy Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Response To Nutrient Levels Positive Regulation Of Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Translation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Nutrient Levels Regulation Of Autophagy Of Mitochondrion Regulation Of Translational Initiation Protein Metabolic Process Apoptotic Process Positive Regulation Of Cell Communication Programmed Cell Death Cell Death Cytoplasmic Translation Response To Starvation Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Golgi Apparatus Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Autophagosome Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Starvation Negative Regulation Of Signal Transduction Autophagosome Organization Regulation Of Apoptotic Process Negative Regulation Of Autophagy Regulation Of Mitophagy Protein Catabolic Process Thymus Development Regulation Of Intracellular Signal Transduction	Zygotic Specification Of Dorsal/ventral Axis Activin Receptor Binding Dorsal/ventral Axis Specification Aortic Valve Morphogenesis Artery Development Ureteric Bud Development I-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Septum Development Heart Valve Development Response To Fluid Shear Stress Heteromeric SMAD Protein Complex Transcription Regulator Inhibitor Activity SMAD Protein Signal Transduction Atrioventricular Valve Morphogenesis Intracellular Signaling Cassette Negative Regulation Of Activin Receptor Signaling Pathway Type I Activin Receptor Binding Negative Regulation Of SMAD Protein Signal Transduction Co-SMAD Binding Pulmonary Valve Morphogenesis Mesonephric Epithelium Development Type I Transforming Growth Factor Beta Receptor Binding Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Ossification Aorta Development Mesonephric Tubule Development R-SMAD Binding Embryonic Axis Specification Response To Laminar Fluid Shear Stress Negative Regulation Of Multicellular Organismal Process Ventricular Septum Development Mitral Valve Morphogenesis Coronary Vasculature Development Protein Sequestering Activity Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Translational Initiation Protein Kinase Activator Activity Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Oligodendrocyte Differentiation Response To External Biotic Stimulus Golgi Apparatus Positive Regulation Of MiRNA Transcription Heart Valve Morphogenesis Negative Regulation Of Osteoblast Differentiation Regulation Of SMAD Protein Signal Transduction
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