FBLN1 and ELN

Number of citations of the paper that reports this interaction (PubMedID 10544250)
0

Data Source:
HPRD (in vitro)

		FBLN1	ELN
Description		fibulin 1	elastin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Region Extracellular Matrix Elastic Fiber
	Molecular Function	Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Fibroblast Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs			Rofecoxib
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses	Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis
GWAS		Blood protein levels ( 30072576) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Diverticular disease ( 30177863) Height ( 31562340)
Interacting Genes		68 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CRIPTO CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 FXR1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KLHL20 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 NUFIP2 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF20 TCF7L2 TLE5 TRIM42 UNKL VCAN YWHAQ	26 interacting genes: ALMS1 ARLN ASS1 ATP2A2 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PLN PRTN3 SPINK1
Entrez ID		2192	2006
HPRD ID		00629	00556
Ensembl ID		ENSG00000077942	ENSG00000049540
Uniprot IDs		A0A8S0LWY1 P23142 Q8NBH6	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Tissue Development Epidermis Development Keratinization Extracellular Matrix Structural Constituent Developmental Process Integrin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Signal Transduction Response To Interleukin-1 Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Angiogenesis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of System Process Anatomical Structure Formation Involved In Morphogenesis Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Development Calcium-independent Cell-matrix Adhesion Embryonic Pattern Specification Adrenal Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding Extracellular Region Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Collagen Binding Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of MiRNA Transcription Cell Migration Regulation Of Spontaneous Synaptic Transmission Activin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process	Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Microfibril Extracellular Matrix Organization Extracellular Structure Organization Calcium Ion-transporting ATPase Complex Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Basement Membrane Extracellular Matrix Binding Regulation Of Multicellular Organismal Process Calcium Ion Binding Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Regulation Of Cardiac Muscle Cell Membrane Potential Humoral Immune Response Killing Of Cells Of Another Organism Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Calcium Ion Import Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Collagen Fibril Organization Extracellular Negative Regulation Of Signal Transduction Relaxation Of Cardiac Muscle Extracellular Matrix Structural Constituent Conferring Compression Resistance Sensory Organ Morphogenesis Cell Killing Negative Regulation Of Calcium Ion Import Azurophil Granule Lumen Relaxation Of Muscle Negative Regulation Of Heart Contraction Response To External Biotic Stimulus Extracellular Exosome Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Circulation Glycosaminoglycan Binding Muscle Cell Cellular Homeostasis Regulation Of The Force Of Heart Contraction Defense Response To Symbiont Negative Regulation Of Signal Transduction Defense Response To Other Organism Extracellular Matrix Assembly Embryonic Organ Morphogenesis Fibronectin Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Endocytosis
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