ELN and SPINK1

Number of citations of the paper that reports this interaction (PubMedID 2093478)
0

Data Source:
HPRD (in vitro)

		ELN	SPINK1
Description		elastin	serine peptidase inhibitor Kazal type 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Elastic Fiber	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly	Nitric Oxide Mediated Signal Transduction Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Developmental Lineage of Pancreatic Acinar Cells
Drugs		Rofecoxib
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis	Hereditary pancreatitis; Hereditary chronic pancreatitis Tropical calcific pancreatitis
GWAS		Diverticular disease ( 30177863) Height ( 31562340)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		26 interacting genes: ALMS1 ARLN ASS1 ATP2A2 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PLN PRTN3 SPINK1	7 interacting genes: ASPH CTRC ELN NRSN1 RRM1 TMPRSS15 UBE3A
Entrez ID		2006	6690
HPRD ID		00556	01341
Ensembl ID		ENSG00000049540	ENSG00000164266
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	P00995
PDB IDs			1CGI 1CGJ 1HPT 7QE8 7QE9
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Microfibril Extracellular Matrix Organization Extracellular Structure Organization Calcium Ion-transporting ATPase Complex Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Basement Membrane Extracellular Matrix Binding Regulation Of Multicellular Organismal Process Calcium Ion Binding Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Regulation Of Cardiac Muscle Cell Membrane Potential Humoral Immune Response Killing Of Cells Of Another Organism Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Calcium Ion Import Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Collagen Fibril Organization Extracellular Negative Regulation Of Signal Transduction Relaxation Of Cardiac Muscle Extracellular Matrix Structural Constituent Conferring Compression Resistance Sensory Organ Morphogenesis Cell Killing Negative Regulation Of Calcium Ion Import Azurophil Granule Lumen Relaxation Of Muscle Negative Regulation Of Heart Contraction Response To External Biotic Stimulus Extracellular Exosome Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Circulation Glycosaminoglycan Binding Muscle Cell Cellular Homeostasis Regulation Of The Force Of Heart Contraction Defense Response To Symbiont Negative Regulation Of Signal Transduction Defense Response To Other Organism Extracellular Matrix Assembly Embryonic Organ Morphogenesis Fibronectin Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Endocytosis	Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Intracellular Chemical Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Monoatomic Cation Homeostasis Serine-type Peptidase Activity Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Activity Sperm Entry Regulation Of Golgi Lumen Acidification Positive Regulation Of Golgi Lumen Acidification Cellular Homeostasis Activation Of Store-operated Calcium Channel Activity Elastic Fiber Serine-type Endopeptidase Activity Positive Regulation Of G0 To G1 Transition Purine Nucleotide Binding Positive Regulation Of Cellular PH Reduction Positive Regulation Of Store-operated Calcium Channel Activity Intracellular Calcium Ion Homeostasis Positive Regulation Of Protein Localization To Lysosome
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