FBLN1 and CCN2

Number of citations of the paper that reports this interaction (PubMedID 9927660)
37

Data Source:
BioGRID (pull down)

		FBLN1	CCN2
Description		fibulin 1	cellular communication network factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Extracellular Matrix Cell Periphery
	Molecular Function	Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Integrin Binding Protein Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Fibroblast Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Cartilage Condensation Ossification Angiogenesis Osteoblast Differentiation Tissue Homeostasis Chondrocyte Differentiation Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Negative Regulation Of Gene Expression Cell Migration Lung Development Regulation Of Chondrocyte Differentiation Chondrocyte Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Regulation Of Developmental Process Positive Regulation Of Stress Fiber Assembly Connective Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		68 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CRIPTO CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 FXR1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KLHL20 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 NUFIP2 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF20 TCF7L2 TLE5 TRIM42 UNKL VCAN YWHAQ	15 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LIMS1 LRP1 MMP14 MTDH RSPH1 TGFB1 TGFB2 TGFB3 VEGFA
Entrez ID		2192	1490
HPRD ID		00629	00412
Ensembl ID		ENSG00000077942	ENSG00000118523
Uniprot IDs		A0A8S0LWY1 P23142 Q8NBH6	P29279 Q5M8T4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Tissue Development Epidermis Development Keratinization Extracellular Matrix Structural Constituent Developmental Process Integrin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Signal Transduction Response To Interleukin-1 Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Angiogenesis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of System Process Anatomical Structure Formation Involved In Morphogenesis Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Development Calcium-independent Cell-matrix Adhesion Embryonic Pattern Specification Adrenal Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding Extracellular Region Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Collagen Binding Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of MiRNA Transcription Cell Migration Regulation Of Spontaneous Synaptic Transmission Activin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process	Extracellular Matrix Regulation Of SMAD Protein Signal Transduction Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Localization Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Adhesion Response To Hypoxia Negative Regulation Of Macrophage Cytokine Production Regulation Of Cell Population Proliferation Response To Decreased Oxygen Levels Growth Factor Activity Response To Growth Factor Positive Regulation Of Cell Differentiation Response To Oxygen Levels Transforming Growth Factor Beta Receptor Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Population Proliferation Cell-cell Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Uterine Wall Breakdown Extracellular Space Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Locomotion Positive Regulation Of Cell Division Positive Regulation Of Metabolic Process Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Localization Cell Junction Organization Gland Morphogenesis Face Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Localization To Plasma Membrane
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