ACSL3 and SMARCAL1

		ACSL3	SMARCAL1
Description		acyl-CoA synthetase long chain family member 3	SNF2 related chromatin remodeling annealing helicase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Kinase Binding Protein Domain Specific Binding Medium-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Fatty Acid-CoA Ligase Activity	Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity ATP-dependent DNA/DNA Annealing Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Neuron Differentiation Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Long-chain Fatty Acid Import Into Cell Positive Regulation Of Secretion Positive Regulation Of Phosphatidylcholine Biosynthetic Process	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II DNA Damage Response Replication Fork Processing T-circle Formation
Pathways		Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases			Schimke immunoosseous dysplasia
GWAS		Mild influenza (H1N1) infection ( 26379185)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter integrity (fractional anisotropy) ( 32358547)
Interacting Genes		9 interacting genes: APP BARD1 CAPS MAP2 MMP13 NDRG1 SMARCAL1 TAS2R14 WEE2-AS1	2 interacting genes: ACSL3 RPA2
Entrez ID		2181	50485
HPRD ID		03845	05969
Ensembl ID		ENSG00000123983	ENSG00000138375
Uniprot IDs		O95573	Q9NZC9
PDB IDs			4MQV
Enriched GO Terms of Interacting Partners?		Main Axon Acetylcholine Receptor Activator Activity Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Lipoprotein Particle Dendrite Development Positive Regulation Of Protein Import Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Apical Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Proximal Neuron Projection Dendritic Branch Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Myeloid Leukocyte Activation Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BRCA1-B Complex Positive Regulation Of Vesicle Transport Along Microtubule Pre-mRNA 5'-splice Site Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Synaptic Vesicle Transport Basal Dendrite Nickel Cation Binding ATP-dependent DNA/DNA Annealing Activity	Positive Regulation Of Phosphatidylcholine Biosynthetic Process Medium-chain Fatty Acid-CoA Ligase Activity Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Very-low-density Lipoprotein Particle Assembly Arachidonate-CoA Ligase Activity Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Phosphatidylcholine Biosynthetic Process Long-chain Fatty Acid Import Into Cell Palmitoyl-CoA Ligase Activity Positive Regulation Of Phospholipid Biosynthetic Process Fatty Acid-CoA Ligase Activity G-rich Strand Telomeric DNA Binding Long-chain Fatty Acid-CoA Ligase Activity Lipid Import Into Cell DNA Replication Factor A Complex Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Phospholipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Plasma Lipoprotein Particle Assembly Regulation Of DNA Damage Checkpoint Protein-lipid Complex Assembly Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Telomeric DNA Binding Mismatch Repair Regulation Of Phospholipid Metabolic Process Base-excision Repair Fatty Acid Derivative Biosynthetic Process Long-chain Fatty Acid Transport Nucleotide-excision Repair Peroxisomal Membrane Positive Regulation Of Protein Localization To Plasma Membrane Damaged DNA Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Localization To Cell Periphery Fatty Acid Derivative Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Sulfur Compound Biosynthetic Process Lipid Droplet Long-chain Fatty Acid Metabolic Process Fatty Acid Transport Acyl-CoA Metabolic Process Positive Regulation Of Protein Localization To Membrane Telomere Maintenance Protein Phosphatase Binding
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