ELK4 and MAPK11

Number of citations of the paper that reports this interaction (PubMedID 9235954)
0

Data Source:
HPRD (in vitro)

		ELK4	MAPK11
Description		ETS transcription factor ELK4	mitogen-activated protein kinase 11
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	MAPK Cascade Osteoblast Differentiation Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Protein Maturation Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Pyroptotic Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To UV-B Cellular Senescence Cellular Response To Virus NLRP1 Inflammasome Complex Assembly
Pathways			NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Drugs			Minocycline KC706 Regorafenib
Diseases		Prostate cancer
GWAS			Acne (severe) ( 24927181) Adult body size ( 32376654)
Interacting Genes		12 interacting genes: BRCA1 FGFR2 FOS ID1 ID2 ID3 MAPK1 MAPK11 MAPK3 MAPK7 MAPK8 SRF	28 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DOT1L DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		2005	5600
HPRD ID		02592	04208
Ensembl ID		ENSG00000158711	ENSG00000185386
Uniprot IDs		P28324 Q8IXL1	Q15759
PDB IDs		1BC7 1BC8 1HBX 1K6O	3GC8 3GC9 3GP0 8YGW
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis Cellular Senescence Cell Differentiation Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Face Development Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Protein Kinase Activity Hematopoietic Or Lymphoid Organ Development Cellular Response To Oxygen-containing Compound Cellular Response To Nutrient Levels Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heart Development Animal Organ Development Regulation Of Multicellular Organismal Development Response To Cytokine Cellular Developmental Process Nucleoplasm Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Thyroid Gland Development Response To Tumor Necrosis Factor Response To Lipopolysaccharide Astrocyte Differentiation Interleukin-34-mediated Signaling Pathway Response To Growth Factor Regulation Of Cell Differentiation Kinase Activity Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Molecule Of Bacterial Origin Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Regulation Of Osteoblast Differentiation Regulation Of Golgi Inheritance Transcription Regulator Inhibitor Activity	Intracellular Signal Transduction Mitogen-activated Protein Kinase P38 Binding Regulation Of Growth Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Growth Chromatin Binding Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Enzyme Binding Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Regulation Of Multicellular Organism Growth Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Response To Stress Mitogen-activated Protein Kinase Binding Regulation Of Developmental Process Chromatin Remodeling Cellular Response To Anisomycin Nucleus Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Phosphatase Activity Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Microglial Cell Activation Response To Anisomycin Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Main Axon Liver Development
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