ELK4 and ID2

Number of citations of the paper that reports this interaction (PubMedID 10022839)
51

Data Source:
HPRD (in vitro)

		ELK4	ID2
Description		ETS transcription factor ELK4	inhibitor of DNA binding 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Transmembrane Transporter Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Natural Killer Cell Differentiation Thigmotaxis Leukocyte Differentiation Membranous Septum Morphogenesis Bundle Of His Development Regulation Of Transcription By RNA Polymerase II Heart Development Circadian Rhythm Adult Locomotory Behavior Entrainment Of Circadian Clock Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Neuron Differentiation B Cell Differentiation Erythrocyte Differentiation Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cell Development Cell Maturation Rhythmic Process Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Cell Morphogenesis Involved In Neuron Differentiation Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation White Fat Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Cellular Senescence Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Neural Precursor Cell Proliferation
Pathways			NGF-stimulated transcription
Drugs
Diseases		Prostate cancer
GWAS			Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 31959851 27182965) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Cognitive decline rate in late mild cognitive impairment ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Mean corpuscular volume ( 28017375) PR interval ( 29127183 30046033 31217584 32439900) Self-reported allergy ( 23817569)
Interacting Genes		12 interacting genes: BRCA1 FGFR2 FOS ID1 ID2 ID3 MAPK1 MAPK11 MAPK3 MAPK7 MAPK8 SRF	56 interacting genes: ADD1 ANAPC1 ANAPC5 ASB4 C22orf39 CDK1 CDK2 DYRK1A DYRK1B ELK1 ELK3 ELK4 ELOC ENKD1 FANCL FNDC11 FRS3 FZR1 GATA4 GFUS HES1 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MSGN1 MYF5 MYF6 MYOD1 MYOG NEDD9 NR0B2 PAX2 PAX5 PAX8 PICK1 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 RHOU RIN3 SREBF1 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TCHP TNS2 UNC119
Entrez ID		2005	3398
HPRD ID		02592	02664
Ensembl ID		ENSG00000158711	ENSG00000115738
Uniprot IDs		P28324 Q8IXL1	Q02363 Q53T66
PDB IDs		1BC7 1BC8 1HBX 1K6O	4AYA
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis Cellular Senescence Cell Differentiation Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Face Development Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Protein Kinase Activity Hematopoietic Or Lymphoid Organ Development Cellular Response To Oxygen-containing Compound Cellular Response To Nutrient Levels Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heart Development Animal Organ Development Regulation Of Multicellular Organismal Development Response To Cytokine Cellular Developmental Process Nucleoplasm Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Thyroid Gland Development Response To Tumor Necrosis Factor Response To Lipopolysaccharide Astrocyte Differentiation Interleukin-34-mediated Signaling Pathway Response To Growth Factor Regulation Of Cell Differentiation Kinase Activity Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Molecule Of Bacterial Origin Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Regulation Of Osteoblast Differentiation Regulation Of Golgi Inheritance Transcription Regulator Inhibitor Activity	Nucleoplasm Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription E-box Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Developmental Process Positive Regulation Of Cell Differentiation Muscle Cell Fate Commitment Regulation Of Lipid Kinase Activity Cellular Response To Starvation RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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