ELK4 and ID3

Number of citations of the paper that reports this interaction (PubMedID 10022839)
51

Data Source:
HPRD (in vitro)

		ELK4	ID3
Description		ETS transcription factor ELK4	inhibitor of DNA binding 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Protein Dimerization Activity Transcription Regulator Inhibitor Activity Leptomycin B Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA Replication Central Nervous System Development Heart Development Muscle Organ Development Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neuron Differentiation Epithelial Cell Differentiation Notochord Development Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Leptomycin B
Pathways			NGF-stimulated transcription
Drugs
Diseases		Prostate cancer
GWAS
Interacting Genes		12 interacting genes: BRCA1 FGFR2 FOS ID1 ID2 ID3 MAPK1 MAPK11 MAPK3 MAPK7 MAPK8 SRF	50 interacting genes: ADD1 ANKS1A ATF3 BOLA2 BOLA2B C22orf39 CBFA2T2 CDK2 CEP350 CNOT3 CREB5 CSK E2F4 ELK1 ELK4 FAM74A1 FHL2 FRS3 GATA4 GNB2 GTF2A1L GUCD1 HES1 HOXA1 ID4 IFI16 IKBKG KAT5 KRTAP26-1 LMO4 MLX MSGN1 MYF5 MYF6 MYOD1 MYOG PAX5 PRDM14 PUF60 RND1 RUNX1T1 SAP30 SDCBP SREBF1 TCF12 TCF3 TCF4 ZNF3 ZNF408 ZNF626
Entrez ID		2005	3399
HPRD ID		02592	02608
Ensembl ID		ENSG00000158711	ENSG00000117318
Uniprot IDs		P28324 Q8IXL1	Q02535
PDB IDs		1BC7 1BC8 1HBX 1K6O	2LFH
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis Cellular Senescence Cell Differentiation Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Face Development Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Protein Kinase Activity Hematopoietic Or Lymphoid Organ Development Cellular Response To Oxygen-containing Compound Cellular Response To Nutrient Levels Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heart Development Animal Organ Development Regulation Of Multicellular Organismal Development Response To Cytokine Cellular Developmental Process Nucleoplasm Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Thyroid Gland Development Response To Tumor Necrosis Factor Response To Lipopolysaccharide Astrocyte Differentiation Interleukin-34-mediated Signaling Pathway Response To Growth Factor Regulation Of Cell Differentiation Kinase Activity Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Molecule Of Bacterial Origin Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Regulation Of Osteoblast Differentiation Regulation Of Golgi Inheritance Transcription Regulator Inhibitor Activity	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding E-box Binding Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Cellular Developmental Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Skeletal Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Nucleoplasm Positive Regulation Of Metabolic Process Transcription Regulator Complex Cell Fate Commitment Negative Regulation Of Macromolecule Biosynthetic Process Muscle Cell Fate Commitment Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development
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