EIF5 and EIF4G2

Number of citations of the paper that reports this interaction (PubMedID 11331597)
28

Data Source:
HPRD (in vitro)

		EIF5	EIF4G2
Description		eukaryotic translation initiation factor 5	eukaryotic translation initiation factor 4 gamma 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synapse	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Nucleotide Binding RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly	Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Regulation Of Cell Cycle
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)	Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: APP CDC42 CEBPA CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN OGT PUM1	19 interacting genes: C1QTNF9 CASP3 CEBPA CREBBP EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 LCOR MKNK1 NCBP1 OGT POLE3 RNF10 SKIL SUMO2 TTC3
Entrez ID		1983	1982
HPRD ID		03417	09084
Ensembl ID		ENSG00000100664	ENSG00000110321
Uniprot IDs		P55010	P78344 Q2TU89
PDB IDs		2E9H 2G2K 2IU1 8OZ0 8PJ2 8PJ3	3D3M 3L6A 4IUL 9JJ7
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translation Translation Factor Activity, RNA Binding Cap-dependent Translational Initiation Post-transcriptional Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Cytosol RNA Binding Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein Metabolic Process Viral Translational Termination-reinitiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Positive Regulation Of Growth MRNA Binding Regulation Of Synapse Organization Sin3-type Complex Translation Initiation Factor Binding Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Catabolic Process Cellular Component Assembly Regulation Of Growth Regulation Of Presynapse Organization Regulation Of Presynapse Assembly PcG Protein Complex Post-transcriptional Gene Silencing Negative Regulation Of Proteolysis Viral Process	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Translation RNA Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin DNA Binding Regulation Of Gene Expression Regulation Of Translation Regulation Of Translational Initiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Protein-RNA Complex Assembly RNA 7-methylguanosine Cap Binding Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Formation Of Cytoplasmic Translation Initiation Complex RNA Binding MRNA Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Translation Factor Activity, RNA Binding Glutamatergic Synapse Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex Response To Glucocorticoid Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Organization Response To Corticosteroid Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Pyroptotic Inflammatory Response DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Negative Regulation Of RNA-dependent RNA Polymerase Activity Eukaryotic Initiation Factor 4G Binding
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