EIF4G2 and EIF2S2

Number of citations of the paper that reports this interaction (PubMedID 16932749)
26

Data Source:
HPRD (in vivo, in vitro)

		EIF4G2	EIF2S2
Description		eukaryotic translation initiation factor 4 gamma 2	eukaryotic translation initiation factor 2 subunit beta
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GO Annotations	Cellular Component	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Synapse
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Zinc Ion Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Regulation Of Cell Cycle	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Male Germ Cell Proliferation Cytoplasmic Translational Initiation Translation Translational Initiation Male Gonad Development
Pathways		ISG15 antiviral mechanism	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		19 interacting genes: C1QTNF9 CASP3 CEBPA CREBBP EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 LCOR MKNK1 NCBP1 OGT POLE3 RNF10 SKIL SUMO2 TTC3	28 interacting genes: AAR2 APLP1 APP CCDC90B CEBPA CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 KIZ NCK1 OGT PLEKHM1 PRKDC TLE1 TNFRSF25 TP53 UNC119 ZBTB16
Entrez ID		1982	8894
HPRD ID		09084	04882
Ensembl ID		ENSG00000110321	ENSG00000125977
Uniprot IDs		P78344 Q2TU89	P20042 Q6IBR8
PDB IDs		3D3M 3L6A 4IUL 9JJ7	6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43 7QP6 8OZ0 8PJ1 8PPL
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Translation RNA Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin DNA Binding Regulation Of Gene Expression Regulation Of Translation Regulation Of Translational Initiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Protein-RNA Complex Assembly RNA 7-methylguanosine Cap Binding Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Formation Of Cytoplasmic Translation Initiation Complex RNA Binding MRNA Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Translation Factor Activity, RNA Binding Glutamatergic Synapse Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex Response To Glucocorticoid Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Organization Response To Corticosteroid Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Pyroptotic Inflammatory Response DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Negative Regulation Of RNA-dependent RNA Polymerase Activity Eukaryotic Initiation Factor 4G Binding	Translation Initiation Factor Activity Regulation Of Translation Eukaryotic Translation Initiation Factor 2B Complex Translational Initiation Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Glial Cell Development Translation Oligodendrocyte Development Central Nervous System Development Cytoplasmic Translational Initiation Response To Heat T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Response To Glucose Signal Transduction Transcription Regulator Complex Cytosol Response To Monosaccharide Cell Surface Receptor Signaling Pathway Response To Hormone Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Response To Carbohydrate Protein-containing Complex Organization Cell Development Regulation Of Apoptotic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Eukaryotic Initiation Factor EIF2 Binding Macromolecule Biosynthetic Process Response To Peptide Hormone Molecular Function Activator Activity Cell Death Cellular Response To Norepinephrine Stimulus Macromolecule Metabolic Process Response To Norepinephrine Protein-containing Complex Assembly Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Protein Domain Specific Binding PML Body Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process B Cell Lineage Commitment
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