SLC26A3 and NHERF2

Number of citations of the paper that reports this interaction (PubMedID 12369822)
0

Data Source:
BioGRID (pull down)

		SLC26A3	NHERF2
Description		solute carrier family 26 member 3	NHERF family PDZ scaffold protein 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Sperm Midpiece	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Antiporter Activity Oxalate Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Bicarbonate Transport Oxalate Transport Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Sulfate Transmembrane Transport Chloride Transmembrane Transport	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Inorganic anion exchange by SLC26 transporters Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
Drugs
Diseases
GWAS		Behavioural changes in frontotemporal lobe dementia ( 29724592) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915573 28067908) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: MET NHERF1 NHERF2	47 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR IFT140 KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		1811	9351
HPRD ID		00544	05946
Ensembl ID		ENSG00000091138	ENSG00000065054
Uniprot IDs		P40879	H3BQS0 Q15599
PDB IDs		7XUH 7XUJ 7XUL 8IET	2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Phosphatase Binding Beta-catenin Binding Hepatocyte Growth Factor Receptor Activity Renal Phosphate Ion Absorption Protein Localization To Plasma Membrane Molecular Adaptor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Morphogenesis Of An Epithelium Identical Protein Binding Hepatocyte Growth Factor Receptor Signaling Pathway Endomembrane System Protein Localization To Cell Periphery Apical Plasma Membrane Protein Localization To Membrane Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Signaling Receptor Binding Intracellular Phosphate Ion Homeostasis Tissue Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis Semaphorin Receptor Activity Endothelial Cell Morphogenesis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cerebrospinal Fluid Circulation Plasma Membrane Protein Complex Stereocilium Tip	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis
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