NHERF2 and IFT140

		NHERF2	IFT140
Description		NHERF family PDZ scaffold protein 2	intraflagellar transport 140
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development
Pathways			Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		47 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR IFT140 KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1	12 interacting genes: CELSR3 CRK DNAJA3 IL32 NEK2 NHERF2 PFDN1 RAB11FIP3 RANBP2 TELO2 TRAP1 ZNF263
Entrez ID		9351	9742
HPRD ID		05946	11093
Ensembl ID		ENSG00000065054	ENSG00000187535
Uniprot IDs		H3BQS0 Q15599	Q96RY7
PDB IDs		2D11 2HE4 2OCS 4P0C	8BBF 8BBG 8FGW 8FH3
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis	Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation
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