SLC26A3

Description		solute carrier family 26 member 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Sperm Midpiece
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Antiporter Activity Oxalate Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Bicarbonate Transport Oxalate Transport Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways		Inorganic anion exchange by SLC26 transporters Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
Drugs
Diseases
GWAS		Behavioural changes in frontotemporal lobe dementia ( 29724592) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915573 28067908) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		3 novel interacting genes: MET NHERF1 NHERF2
Interacting Genes		3 interacting genes: MET NHERF1 NHERF2
Entrez ID		1811
HPRD ID		00544
Ensembl ID		ENSG00000091138
Uniprot IDs		P40879
PDB IDs		7XUH 7XUJ 7XUL 8IET
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Phosphatase Binding Beta-catenin Binding Hepatocyte Growth Factor Receptor Activity Renal Phosphate Ion Absorption Protein Localization To Plasma Membrane Molecular Adaptor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Morphogenesis Of An Epithelium Identical Protein Binding Hepatocyte Growth Factor Receptor Signaling Pathway Endomembrane System Protein Localization To Cell Periphery Apical Plasma Membrane Protein Localization To Membrane Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Signaling Receptor Binding Intracellular Phosphate Ion Homeostasis Tissue Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis Semaphorin Receptor Activity Endothelial Cell Morphogenesis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cerebrospinal Fluid Circulation Plasma Membrane Protein Complex Stereocilium Tip
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