SPTSSB and DRD3

		SPTSSB	DRD3
Description		serine palmitoyltransferase small subunit B	dopamine receptor D3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Plasma Membrane Membrane Synapse
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Endoplasmic Reticulum Organization Sphingolipid Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process	Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Internalization Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Visual Learning Response To Xenobiotic Stimulus Regulation Of Dopamine Secretion Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Response To Cocaine Dopamine Metabolic Process Regulation Of Potassium Ion Transport Response To Morphine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonate Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Secretion By Cell
Pathways		Sphingolipid de novo biosynthesis	Dopamine receptors G alpha (i) signalling events
Drugs			Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Haloperidol Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Norclozapine Cariprazine Mianserin Asenapine Amisulpride Sarizotan Sumanirole Nandrolone decanoate Captodiame AS-8112 Blonanserin Pipamperone Tianeptine Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Piribedil Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		IgG1 response to Plasmodium falciparum antigen (GLURP) ( 26741287) Morning person ( 30696823) Number of sexual partners ( 30643258) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Chronotype ( 30696823) Feeling hurt ( 29500382) Personality dimensions ( 23903073) Smooth-surface caries ( 24556642)
Interacting Genes		1 interacting genes: DRD3	19 interacting genes: CLIC6 DRD1 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 GSK3B MPDZ NCK1 NCS1 POLE2 RDX RGS9 SPTSSB
Entrez ID		165679	1814
HPRD ID		16476	00540
Ensembl ID		ENSG00000196542	ENSG00000151577
Uniprot IDs		Q6ZWB5 Q8NFR3	A1A4V4 A8K8E4 E9PCM4 P35462 X5D2G4
PDB IDs			3PBL 7CMU 7CMV 8IRT 9F33 9F34
Enriched GO Terms of Interacting Partners?		Reflex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Receptor Internalization Musculoskeletal Movement, Spinal Reflex Action Synaptic Transmission, Dopaminergic Prepulse Inhibition Behavioral Response To Cocaine Negative Regulation Of Cytosolic Calcium Ion Concentration Response To Histamine Response To Morphine Arachidonate Secretion Musculoskeletal Movement Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Oligodendrocyte Differentiation Dopamine Neurotransmitter Receptor Activity Regulation Of Neurotransmitter Uptake G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Dopamine Secretion Negative Regulation Of Glial Cell Differentiation Acid Secretion Dopamine Metabolic Process Response To Cocaine Negative Regulation Of Gliogenesis Regulation Of Catecholamine Secretion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Oligodendrocyte Differentiation Catecholamine Metabolic Process Positive Regulation Of Cytokinesis Negative Regulation Of Synaptic Transmission Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Long-chain Fatty Acid Transport Visual Learning Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Social Behavior Visual Behavior Circadian Regulation Of Gene Expression Receptor Internalization Biogenic Amine Metabolic Process Regulation Of Glial Cell Differentiation Negative Regulation Of Protein Secretion Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Amine Transport	Cell Cortex Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeletal Protein Binding G Protein-coupled Dopamine Receptor Signaling Pathway Actin Binding D2 Dopamine Receptor Binding Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Localization Vesicle Membrane Presynaptic Modulation Of Chemical Synaptic Transmission Cortical Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cadherin Binding Plasma Membrane Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Neuron Migration Cytoplasm Translation Elongation Factor Activity Regulation Of Actin Filament Organization Actomyosin Structure Organization Glutamatergic Synapse Regulation Of Protein Localization Negative Regulation Of Protein Catabolic Process Regulation Of Actin Filament Polymerization Spectrin Binding Cortical Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Intracellular Transport Regulation Of Metal Ion Transport Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Response To Amphetamine Regulation Of Actin Filament Length Positive Regulation Of Potassium Ion Transport Regulation Of Protein Localization To Cell Periphery COP9 Signalosome Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Transport Regulation Of Monoatomic Ion Transport Extracellular Exosome Structural Molecule Activity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Dendritic Shaft Positive Regulation Of Cytoskeleton Organization
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