DRD3 and MPDZ

Number of citations of the paper that reports this interaction (PubMedID 14499480)
0

Data Source:
HPRD (two hybrid)

		DRD3	MPDZ
Description		dopamine receptor D3	multiple PDZ domain crumbs cell polarity complex component
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Cytoplasm Plasma Membrane Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cell Projection Neuron Projection Apical Part Of Cell Synapse Anchoring Junction
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding	Protein Binding
	Biological Process	Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Internalization Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Visual Learning Response To Xenobiotic Stimulus Regulation Of Dopamine Secretion Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Response To Cocaine Dopamine Metabolic Process Regulation Of Potassium Ion Transport Response To Morphine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonate Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Secretion By Cell	Tight Junction Assembly
Pathways		Dopamine receptors G alpha (i) signalling events
Drugs		Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Haloperidol Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Norclozapine Cariprazine Mianserin Asenapine Amisulpride Sarizotan Sumanirole Nandrolone decanoate Captodiame AS-8112 Blonanserin Pipamperone Tianeptine Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Piribedil Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 30696823) Feeling hurt ( 29500382) Personality dimensions ( 23903073) Smooth-surface caries ( 24556642)	Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Corneal hysteresis ( 30894546 32716492) Corneal structure ( 23291589) Heel bone mineral density ( 28869591 30598549) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: CLIC6 DRD1 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 GSK3B MPDZ NCK1 NCS1 POLE2 RDX RGS9 SPTSSB	19 interacting genes: ABCA1 CAMK2A CCDC88C CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PELI2 PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2 VANGL2
Entrez ID		1814	8777
HPRD ID		00540	09155
Ensembl ID		ENSG00000151577	ENSG00000107186
Uniprot IDs		A1A4V4 A8K8E4 E9PCM4 P35462 X5D2G4	O75970
PDB IDs		3PBL 7CMU 7CMV 8IRT 9F33 9F34	2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?		Cell Cortex Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeletal Protein Binding G Protein-coupled Dopamine Receptor Signaling Pathway Actin Binding D2 Dopamine Receptor Binding Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Localization Vesicle Membrane Presynaptic Modulation Of Chemical Synaptic Transmission Cortical Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cadherin Binding Plasma Membrane Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Neuron Migration Cytoplasm Translation Elongation Factor Activity Regulation Of Actin Filament Organization Actomyosin Structure Organization Glutamatergic Synapse Regulation Of Protein Localization Negative Regulation Of Protein Catabolic Process Regulation Of Actin Filament Polymerization Spectrin Binding Cortical Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Intracellular Transport Regulation Of Metal Ion Transport Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Response To Amphetamine Regulation Of Actin Filament Length Positive Regulation Of Potassium Ion Transport Regulation Of Protein Localization To Cell Periphery COP9 Signalosome Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Transport Regulation Of Monoatomic Ion Transport Extracellular Exosome Structural Molecule Activity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Dendritic Shaft Positive Regulation Of Cytoskeleton Organization	Regulation Of Biological Quality Plasma Membrane Cell-cell Junction Regulation Of Bicellular Tight Junction Assembly PDZ Domain Binding Regulation Of Cell Communication Regulation Of Signaling Maintenance Of Blood-brain Barrier Tight Junction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Learning Visual Learning Regulation Of Neuronal Synaptic Plasticity Visual Behavior Regulation Of MAPK Cascade Positive Regulation Of Bicellular Tight Junction Assembly Lateral Plasma Membrane Cell Junction Signal Transduction Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Endothelial Intestinal Barrier G Protein-coupled Receptor Signaling Pathway Associative Learning Response To Alcohol Positive Regulation Of Signal Transduction Regulation Of Establishment Of Endothelial Barrier Learning Or Memory Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Response To Ethanol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Ruffle Organization Cognition Bicellular Tight Junction Regulation Of Long-term Neuronal Synaptic Plasticity Phosphatidylinositol-3,4-bisphosphate Binding Face Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress
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