AP1G1 and CCDC91

Number of citations of the paper that reports this interaction (PubMedID 12808037)
46

Data Source:
BioGRID (pull down)

		AP1G1	CCDC91
Description		adaptor related protein complex 1 subunit gamma 1	coiled-coil domain containing 91
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Intracellular Vesicle Presynapse	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Protein Binding Collagen Binding Kinesin Binding GTP-dependent Protein Binding Small GTPase Binding Clathrin Adaptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Synaptic Vesicle Endocytosis Platelet Dense Granule Organization Golgi To Lysosome Transport Basolateral Protein Secretion Melanosome Assembly	Protein Transport Golgi Vesicle Transport Golgi To Lysosome Transport
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Post bronchodilator FEV1 ( 26634245) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)	Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (velocity of sound) ( 28472463) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) FEV1 ( 30804560) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hand osteoarthritis severity (hand Klsum) ( 33055079) Heel bone mineral density ( 30598549) Height ( 25282103 23563607 31562340 20881960 28552196) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082 28166213) Lung function (FVC) ( 26635082 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Narrowest width of the femoral neck ( 30888730) Obesity-related traits ( 23251661) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis of the hand ( 28855172) Peak expiratory flow ( 30804560) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
Interacting Genes		31 interacting genes: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CCDC91 CLINT1 CLTC DNER EPS15 GGA1 GGA2 GGA3 HEATR5B KIF13A MAP1A PLK2 PSEN2 RABEP1 RABGEF1 SNX9 SPTB SYNRG SYP UBL7 UPF1 ZNF512B	12 interacting genes: AP1G1 CDC37 DAPK2 ECT2 EWSR1 GGA1 GGA2 LNX1 PRR5L SYNRG TESC TMTC1
Entrez ID		164	55297
HPRD ID		04637	16905
Ensembl ID		ENSG00000166747	ENSG00000123106
Uniprot IDs		A0A140VJE7 O43747 Q8IY97	Q05D28 Q7Z6B0
PDB IDs		1IU1	1OM9
Enriched GO Terms of Interacting Partners?		Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Clathrin-coated Vesicle AP-1 Adaptor Complex Intracellular Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Golgi Apparatus Early Endosome Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Endocytosis Endosomal Transport Golgi To Plasma Membrane Transport Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Golgi To Plasma Membrane Protein Transport Import Into Cell Cytoplasmic Vesicle Golgi Vesicle Transport Trans-Golgi Network Establishment Of Protein Localization To Plasma Membrane Basolateral Protein Secretion Clathrin-coated Pit Clathrin Binding Endosome Melanosome Organization Cytoplasmic Vesicle Membrane Pigment Granule Organization Retrograde Transport, Endosome To Golgi Cytosol Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Localization Within Membrane Melanosome Assembly Clathrin Adaptor Activity Clathrin Coat Assembly Platelet Dense Granule Organization Receptor-mediated Endocytosis Protein Localization To Membrane Vesicle Organization Membrane Coat Protein Localization To Cell Surface Protein Localization To Plasma Membrane Ubiquitin Binding Phosphatidylinositol Binding	Establishment Of Protein Localization Small GTPase Binding Clathrin-coated Vesicle Protein Transport Post-Golgi Vesicle-mediated Transport AP-1 Adaptor Complex Trans-Golgi Network Protein Localization To Plasma Membrane Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Surface Intracellular Protein Transport Protein Localization To Cell Periphery Intracellular Protein Localization Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Eosinophil Chemotaxis Autophagosome Lumen Golgi Vesicle Transport Golgi To Plasma Membrane Transport Protein Localization To Membrane Synaptic Vesicle Budding From Endosome Golgi Apparatus HSP90-CDC37 Chaperone Complex Positive Regulation Of Eosinophil Migration Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Transport Centralspindlin Complex Regulation Of Protein Phosphorylation Positive Regulation Of Sodium:proton Antiporter Activity Ubiquitin Binding Cellular Localization Phosphatidylinositol Binding Regulation Of Phosphorylation Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation
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