KRT72 and KRT74

		KRT72	KRT74
Description		keratin 72	keratin 74
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament Extracellular Exosome	Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding
	Biological Process	Keratinization Intermediate Filament Organization	Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases			Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		High density lipoprotein cholesterol levels ( 30498476)	Venous thromboembolism ( 32232851)
Interacting Genes		33 interacting genes: BCDIN3D BLOC1S6 HSPB1 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT20 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 KRT74 KRT78 KRT80 LARP4 MYL6B SP7 TAMALIN UBC	19 interacting genes: KRT13 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT72 LMO4
Entrez ID		140807	121391
HPRD ID		09746	10504
Ensembl ID		ENSG00000170486	ENSG00000170484
Uniprot IDs		B4DXK4 Q14CN4	Q7RTS7
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Morphogenesis Of An Epithelium Epithelial Cell Differentiation Cytoskeleton Organization Tissue Morphogenesis Cytoskeleton Organelle Organization Anatomical Structure Morphogenesis Extracellular Exosome Cytosol Cell Differentiation Cellular Developmental Process Hair Cycle Intermediate Filament Cytoskeleton Structural Constituent Of Cytoskeleton Developmental Process Keratinization Epidermis Development Hair Follicle Morphogenesis Cornified Envelope Tissue Development Hair Cycle Process Cell Periphery Keratin Filament Binding Negative Regulation Of Protein Kinase C Signaling Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Supramolecular Fiber Organization Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Organelle Organization Cellular Developmental Process Extracellular Exosome Developmental Process Cytosol Hair Cycle Structural Constituent Of Cytoskeleton Epidermis Development Hair Follicle Morphogenesis Tissue Development Intermediate Filament Cytoskeleton Keratinization Terminal Web Ventral Spinal Cord Interneuron Differentiation Hair Cycle Process Keratinocyte Migration Spinal Cord Motor Neuron Cell Fate Specification
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