ZNF440 and MAP4K5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		ZNF440	MAP4K5
Description		zinc finger protein 440	mitogen-activated protein kinase kinase kinase kinase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Plasma Membrane Cilium
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	MAPK Cascade Intracellular Signal Transduction
Pathways		Generic Transcription Pathway
Drugs			Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) White blood cell count ( 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)
Interacting Genes		36 interacting genes: CARD10 CCDC136 CCNDBP1 CLK2 CSNK2A1 CYSRT1 FHL5 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 KRTAP5-7 KRTAP5-9 KRTAP9-3 LMNA MAP4K5 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PAX9 PJA1 STX1A TRAF1 XBP1 ZNF330	14 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK IFT88 NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440
Entrez ID		126070	11183
HPRD ID		11718	05374
Ensembl ID		ENSG00000171295	ENSG00000012983
Uniprot IDs		Q8IYI8	B3KWC4 Q9Y4K4
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Cytosol	Phosphotyrosine Residue Binding Protein-containing Complex Regulation Of Dendrite Development Helper T Cell Diapedesis Regulation Of Cellular Component Organization Ephrin Receptor Binding Response To External Biotic Stimulus Cerebellar Neuron Development Regulation Of Immune Response Regulation Of Mononuclear Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Plasma Membrane Bounded Cell Projection Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Regulation Of T Cell Migration Regulation Of Metabolic Process Enzyme Binding Diapedesis Regulation Of Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neuron Projection Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Regulation Of Lymphocyte Migration Negative Regulation Of Immune Response Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Transforming Growth Factor Beta Regulation Of Leukocyte Migration Protein Domain Specific Binding Leukocyte Migration Regulation Of Anatomical Structure Morphogenesis Immune System Process Signaling Adaptor Activity Postsynaptic Specialization Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Cytosol Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Nitric Oxide
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